Home > Publications Database > Illicit stimulant use is associated with abnormal substantia nigra morphology in humans. > print

001     136830
005     20240321220137.0
024 7 _ |a 10.1371/journal.pone.0056438
|2 doi
024 7 _ |a pmid:23418568
|2 pmid
024 7 _ |a pmc:PMC3572078
|2 pmc
037 _ _ |a DZNE-2020-03152
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Todd, Gabrielle
|0 P:(DE-HGF)0
|b 0
|e Corresponding author
245 _ _ |a Illicit stimulant use is associated with abnormal substantia nigra morphology in humans.
260 _ _ |a San Francisco, California, US
|c 2013
|b PLOS
264 _ 1 |3 online
|2 Crossref
|b Public Library of Science (PLoS)
|c 2013-02-13
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1602585045_27776
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to investigate the long-term effect of stimulant use on the morphology of the human substantia nigra. We hypothesised that history of illicit stimulant use is associated with an abnormally bright and enlarged substantia nigra (termed ‘hyperechogenicity’) when viewed with transcranial sonography. Substantia nigra morphology was assessed in abstinent stimulant users (n = 36; 31±9 yrs) and in two groups of control subjects: non-drug users (n = 29; 24±5 yrs) and cannabis users (n = 12; 25±7 yrs). Substantia nigra morphology was viewed with transcranial sonography and the area of echogenicity at the anatomical site of the substantia nigra was measured at its greatest extent. The area of substantia nigra echogenicity was significantly larger in the stimulant group (0.273±0.078 cm2) than in the control (0.201±0.054 cm2; P<0.001) and cannabis (0.202±0.045 cm2; P<0.007) groups. 53% of stimulant users exhibited echogenicity that exceeded the 90th percentile for the control group. The results of the current study suggest that individuals with a history of illicit stimulant use exhibit abnormal substantia nigra morphology. Substantia nigra hyperechogenicity is a strong risk factor for developing Parkinson's disease later in life and further research is required to determine if the observed abnormality in stimulant users is associated with a functional deficit of the nigro-striatal system.
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
|0 G:(DE-HGF)POF3-345
|c POF3-345
|f POF III
|x 0
542 _ _ |i 2013-02-13
|2 Crossref
|u http://creativecommons.org/licenses/by/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Central Nervous System Stimulants
|2 NLM Chemicals
650 _ 7 |a Methamphetamine
|0 44RAL3456C
|2 NLM Chemicals
650 _ 7 |a Cocaine
|0 I5Y540LHVR
|2 NLM Chemicals
650 _ 7 |a N-Methyl-3,4-methylenedioxyamphetamine
|0 KE1SEN21RM
|2 NLM Chemicals
650 _ 2 |a Adolescent
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Central Nervous System Stimulants: poisoning
|2 MeSH
650 _ 2 |a Cocaine: poisoning
|2 MeSH
650 _ 2 |a Drug Users
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Methamphetamine: poisoning
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a N-Methyl-3,4-methylenedioxyamphetamine: poisoning
|2 MeSH
650 _ 2 |a Reproducibility of Results
|2 MeSH
650 _ 2 |a Substantia Nigra: diagnostic imaging
|2 MeSH
650 _ 2 |a Substantia Nigra: drug effects
|2 MeSH
650 _ 2 |a Surveys and Questionnaires
|2 MeSH
650 _ 2 |a Ultrasonography, Doppler, Transcranial: methods
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
700 1 _ |a Noyes, Carolyn
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Flavel, Stanley C
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Della Vedova, Chris B
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Spyropoulos, Peter
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Chatterton, Barry
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Berg, Daniela
|0 P:(DE-2719)2000059
|b 6
|u dzne
700 1 _ |a White, Jason M
|0 P:(DE-HGF)0
|b 7
773 1 8 |a 10.1371/journal.pone.0056438
|b : Public Library of Science (PLoS), 2013-02-13
|n 2
|p e56438
|3 journal-article
|2 Crossref
|t PLoS ONE
|v 8
|y 2013
|x 1932-6203
773 _ _ |a 10.1371/journal.pone.0056438
|g Vol. 8, no. 2, p. e56438 -
|0 PERI:(DE-600)2267670-3
|n 2
|q 8:2|p e56438
|t PLOS ONE
|v 8
|y 2013
|x 1932-6203
856 4 _ |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056438
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572078
856 4 _ |u https://pub.dzne.de/record/136830/files/4917.PDF
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/136830/files/4917.gif?subformat=icon
|x icon
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/136830/files/4917.jpg?subformat=icon-1440
|x icon-1440
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/136830/files/4917.jpg?subformat=icon-180
|x icon-180
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/136830/files/4917.jpg?subformat=icon-640
|x icon-640
|y OpenAccess
909 C O |o oai:pub.dzne.de:136830
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 6
|6 P:(DE-2719)2000059
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-345
|2 G:(DE-HGF)POF3-300
|v Population Studies and Genetics
|x 0
914 1 _ |y 2013
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b PLOS ONE : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 1 _ |0 I:(DE-2719)5000055
|k AG Berg
|l Parkinson's Disease Genetics AG Berg
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)5000055
980 1 _ |a FullTexts
999 C 5 |9 -- missing cx lookup --
|a 10.1615/CritRevNeurobiol.v17.i2.30
|2 Crossref
|o 10.1615/CritRevNeurobiol.v17.i2.30
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.pneurobio.2005.04.003
|2 Crossref
|o 10.1016/j.pneurobio.2005.04.003
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1600-0773.1993.tb01331.x
|2 Crossref
|o 10.1111/j.1600-0773.1993.tb01331.x
999 C 5 |y 2001
|2 Crossref
|o H Kalant 2001
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0006-2952(76)90432-9
|2 Crossref
|o 10.1016/0006-2952(76)90432-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0006-2952(97)00405-X
|2 Crossref
|o 10.1016/S0006-2952(97)00405-X
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.15-05-04102.1995
|2 Crossref
|o 10.1523/JNEUROSCI.15-05-04102.1995
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.18-06-01979.1998
|2 Crossref
|o 10.1523/JNEUROSCI.18-06-01979.1998
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.2820058
|2 Crossref
|o 10.1126/science.2820058
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1749-6632.2009.05141.x
|2 Crossref
|o 10.1111/j.1749-6632.2009.05141.x
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.21-23-09414.2001
|2 Crossref
|o 10.1523/JNEUROSCI.21-23-09414.2001
999 C 5 |9 -- missing cx lookup --
|a 10.1176/appi.ajp.158.12.2015
|2 Crossref
|o 10.1176/appi.ajp.158.12.2015
999 C 5 |y 1987
|2 Crossref
|o DL Commins 1987
999 C 5 |y 1996
|2 Crossref
|o R Lew 1996
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0006-2952(87)90566-1
|2 Crossref
|o 10.1016/0006-2952(87)90566-1
999 C 5 |y 1992
|2 Crossref
|o GA Ricaurte 1992
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0140-6736(98)04329-3
|2 Crossref
|o 10.1016/S0140-6736(98)04329-3
999 C 5 |9 -- missing cx lookup --
|a 10.1177/0269881108097724
|2 Crossref
|o 10.1177/0269881108097724
999 C 5 |9 -- missing cx lookup --
|a 10.1124/pr.55.3.3
|2 Crossref
|o 10.1124/pr.55.3.3
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0893-133X(01)00366-9
|2 Crossref
|o 10.1016/S0893-133X(01)00366-9
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.19-12-05096.1999
|2 Crossref
|o 10.1523/JNEUROSCI.19-12-05096.1999
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1353-8020(08)70043-9
|2 Crossref
|o 10.1016/S1353-8020(08)70043-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0074-7742(10)90002-0
|2 Crossref
|o 10.1016/S0074-7742(10)90002-0
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s004150170114
|2 Crossref
|o 10.1007/s004150170114
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.21861
|2 Crossref
|o 10.1002/mds.21861
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awl042
|2 Crossref
|o 10.1093/brain/awl042
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00415-006-0403-9
|2 Crossref
|o 10.1007/s00415-006-0403-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1474-4422(08)70239-4
|2 Crossref
|o 10.1016/S1474-4422(08)70239-4
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0074-7742(10)90009-3
|2 Crossref
|o 10.1016/S0074-7742(10)90009-3
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0301-5629(99)00046-0
|2 Crossref
|o 10.1016/S0301-5629(99)00046-0
999 C 5 |9 -- missing cx lookup --
|a 10.1001/archneur.59.6.999
|2 Crossref
|o 10.1001/archneur.59.6.999
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.20550
|2 Crossref
|o 10.1002/mds.20550
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00702-010-0504-6
|2 Crossref
|o 10.1007/s00702-010-0504-6
999 C 5 |9 -- missing cx lookup --
|a 10.1212/01.WNL.0000144276.29988.C3
|2 Crossref
|o 10.1212/01.WNL.0000144276.29988.C3
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2009.05.072
|2 Crossref
|o 10.1016/j.neuroimage.2009.05.072
999 C 5 |9 -- missing cx lookup --
|a 10.1001/archneurol.2011.141
|2 Crossref
|o 10.1001/archneurol.2011.141
999 C 5 |9 -- missing cx lookup --
|a 10.1097/WNR.0b013e3282f0d4f4
|2 Crossref
|o 10.1097/WNR.0b013e3282f0d4f4
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/114.5.2283
|2 Crossref
|o 10.1093/brain/114.5.2283
999 C 5 |9 -- missing cx lookup --
|a 10.1385/NMM:4:1-2:95
|2 Crossref
|o 10.1385/NMM:4:1-2:95
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.legalmed.2004.11.002
|2 Crossref
|o 10.1016/j.legalmed.2004.11.002
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.clinph.2009.08.016
|2 Crossref
|o 10.1016/j.clinph.2009.08.016
999 C 5 |2 Crossref
|o
999 C 5 |9 -- missing cx lookup --
|a 10.2466/pms.1995.80.3.732
|2 Crossref
|o 10.2466/pms.1995.80.3.732
999 C 5 |9 -- missing cx lookup --
|a 10.1037/t00742-000
|2 Crossref
|o 10.1037/t00742-000
999 C 5 |9 -- missing cx lookup --
|a 10.1002/1097-4679(197804)34:2<437::AID-JCLP2270340239>3.0.CO;2-K
|2 Crossref
|o 10.1002/1097-4679(197804)34:2<437::AID-JCLP2270340239>3.0.CO;2-K
999 C 5 |y 1999
|2 Crossref
|o TN Tombaugh 1999
999 C 5 |9 -- missing cx lookup --
|a 10.1037/1040-3590.4.3.363
|2 Crossref
|o 10.1037/1040-3590.4.3.363
999 C 5 |9 -- missing cx lookup --
|a 10.1093/arclin/acq006
|2 Crossref
|o 10.1093/arclin/acq006
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0028-3932(71)90067-4
|2 Crossref
|o 10.1016/0028-3932(71)90067-4
999 C 5 |y 2007
|2 Crossref
|o YW Huang 2007
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.21628
|2 Crossref
|o 10.1002/mds.21628
999 C 5 |9 -- missing cx lookup --
|a 10.1080/10826080500411528
|2 Crossref
|o 10.1080/10826080500411528
999 C 5 |9 -- missing cx lookup --
|a 10.1002/(SICI)1098-2396(199601)22:1<63::AID-SYN7>3.0.CO;2-G
|2 Crossref
|o 10.1002/(SICI)1098-2396(199601)22:1<63::AID-SYN7>3.0.CO;2-G
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.53.5.1026
|2 Crossref
|o 10.1212/WNL.53.5.1026
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.psychres.2008.10.034
|2 Crossref
|o 10.1016/j.psychres.2008.10.034
999 C 5 |9 -- missing cx lookup --
|a 10.1136/tc.2010.040287
|2 Crossref
|o 10.1136/tc.2010.040287
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.ultrasmedbio.2009.12.001
|2 Crossref
|o 10.1016/j.ultrasmedbio.2009.12.001
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1369-1600.2008.00129.x
|2 Crossref
|o 10.1111/j.1369-1600.2008.00129.x
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.56.1.13
|2 Crossref
|o 10.1212/WNL.56.1.13
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.ultrasmedbio.2007.03.013
|2 Crossref
|o 10.1016/j.ultrasmedbio.2007.03.013
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.23263
|2 Crossref
|o 10.1002/mds.23263

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21