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000136839 0247_ $$2doi$$a10.1016/j.molcel.2013.01.036
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000136839 041__ $$aEnglish
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000136839 1001_ $$0P:(DE-2719)9000425$$aMüller-Rischart, A. Kathrin$$b0
000136839 245__ $$aThe E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
000136839 260__ $$aNew York, NY$$bElsevier$$c2013
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000136839 520__ $$aParkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease, has a wide neuroprotective activity, preventing cell death in various stress paradigms. We identified a stress-protective pathway regulated by parkin that links NF-κB signaling and mitochondrial integrity via linear ubiquitination. Under cellular stress, parkin is recruited to the linear ubiquitin assembly complex and increases linear ubiquitination of NF-κB essential modulator (NEMO), which is essential for canonical NF-κB signaling. As a result, the mitochondrial guanosine triphosphatase OPA1 is transcriptionally upregulated via NF-κB-responsive promoter elements for maintenance of mitochondrial integrity and protection from stress-induced cell death. Parkin-induced stress protection is lost in the absence of either NEMO or OPA1, but not in cells defective for the mitophagy pathway. Notably, in parkin-deficient cells linear ubiquitination of NEMO, activation of NF-κB, and upregulation of OPA1 are significantly reduced in response to TNF-α stimulation, supporting the physiological relevance of parkin in regulating this antiapoptotic pathway.
000136839 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000136839 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x1
000136839 542__ $$2Crossref$$i2013-03-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000136839 542__ $$2Crossref$$i2014-03-26$$uhttps://www.elsevier.com/open-access/userlicense/1.0/
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000136839 650_7 $$2NLM Chemicals$$aIntracellular Signaling Peptides and Proteins
000136839 650_7 $$2NLM Chemicals$$aNEMO protein, mouse
000136839 650_7 $$2NLM Chemicals$$aNF-kappa B
000136839 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aUbiquitin-Protein Ligases
000136839 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aparkin protein
000136839 650_2 $$2MeSH$$aAnimals
000136839 650_2 $$2MeSH$$aApoptosis
000136839 650_2 $$2MeSH$$aFibroblasts: metabolism
000136839 650_2 $$2MeSH$$aHEK293 Cells
000136839 650_2 $$2MeSH$$aHumans
000136839 650_2 $$2MeSH$$aIntracellular Signaling Peptides and Proteins: genetics
000136839 650_2 $$2MeSH$$aIntracellular Signaling Peptides and Proteins: metabolism
000136839 650_2 $$2MeSH$$aMice
000136839 650_2 $$2MeSH$$aMice, Knockout
000136839 650_2 $$2MeSH$$aMitochondria: metabolism
000136839 650_2 $$2MeSH$$aNF-kappa B: genetics
000136839 650_2 $$2MeSH$$aNF-kappa B: metabolism
000136839 650_2 $$2MeSH$$aNeurons: metabolism
000136839 650_2 $$2MeSH$$aParkinson Disease: genetics
000136839 650_2 $$2MeSH$$aParkinson Disease: metabolism
000136839 650_2 $$2MeSH$$aSignal Transduction
000136839 650_2 $$2MeSH$$aTransfection
000136839 650_2 $$2MeSH$$aUbiquitin-Protein Ligases: genetics
000136839 650_2 $$2MeSH$$aUbiquitin-Protein Ligases: metabolism
000136839 650_2 $$2MeSH$$aUbiquitination: genetics
000136839 7001_ $$0P:(DE-HGF)0$$aPilsl, Anna$$b1
000136839 7001_ $$0P:(DE-HGF)0$$aBeaudette, Patrick$$b2
000136839 7001_ $$0P:(DE-HGF)0$$aPatra, Maria$$b3
000136839 7001_ $$0P:(DE-HGF)0$$aHadian, Kamyar$$b4
000136839 7001_ $$0P:(DE-HGF)0$$aFunke, Maria$$b5
000136839 7001_ $$0P:(DE-HGF)0$$aPeis, Regina$$b6
000136839 7001_ $$0P:(DE-HGF)0$$aDeinlein, Alexandra$$b7
000136839 7001_ $$0P:(DE-HGF)0$$aSchweimer, Carolin$$b8
000136839 7001_ $$0P:(DE-2719)2810327$$aKuhn, Peer-Hendrik$$b9
000136839 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan F$$b10
000136839 7001_ $$0P:(DE-HGF)0$$aMotori, Elisa$$b11
000136839 7001_ $$0P:(DE-HGF)0$$aHrelia, Silvana$$b12
000136839 7001_ $$0P:(DE-2719)2000028$$aWurst, Wolfgang$$b13
000136839 7001_ $$0P:(DE-HGF)0$$aTrümbach, Dietrich$$b14
000136839 7001_ $$0P:(DE-HGF)0$$aLanger, Thomas$$b15
000136839 7001_ $$0P:(DE-HGF)0$$aKrappmann, Daniel$$b16
000136839 7001_ $$0P:(DE-HGF)0$$aDittmar, Gunnar$$b17
000136839 7001_ $$0P:(DE-2719)9000396$$aTatzelt, Jörg$$b18
000136839 7001_ $$0P:(DE-2719)9000369$$aWinklhofer, Konstanze F$$b19$$eLast author
000136839 77318 $$2Crossref$$3journal-article$$a10.1016/j.molcel.2013.01.036$$b : Elsevier BV, 2013-03-01$$n5$$p908-921$$tMolecular Cell$$v49$$x1097-2765$$y2013
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