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@ARTICLE{Wiener:136867,
      author       = {Wiener, Jan M and de Condappa, Olivier and Harris, Mathew A
                      and Wolbers, Thomas},
      title        = {{M}aladaptive bias for extrahippocampal navigation
                      strategies in aging humans.},
      journal      = {The journal of neuroscience},
      volume       = {33},
      number       = {14},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.57413},
      reportid     = {DZNE-2020-03189},
      pages        = {6012-6017},
      year         = {2013},
      abstract     = {Efficient spatial navigation requires not only accurate
                      spatial knowledge but also the selection of appropriate
                      strategies. Using a novel paradigm that allowed us to
                      distinguish between beacon, associative cue, and place
                      strategies, we investigated the effects of cognitive aging
                      on the selection and adoption of navigation strategies in
                      humans. Participants were required to rejoin a previously
                      learned route encountered from an unfamiliar direction.
                      Successful performance required the use of an allocentric
                      place strategy, which was increasingly observed in young
                      participants over six experimental sessions. In contrast,
                      older participants, who were able to recall the route when
                      approaching intersections from the same direction as during
                      encoding, failed to use the correct place strategy when
                      approaching intersections from novel directions. Instead,
                      they continuously used a beacon strategy and showed no
                      evidence of changing their behavior across the six sessions.
                      Given that this bias was already apparent in the first
                      experimental session, the inability to adopt the correct
                      place strategy is not related to an inability to switch from
                      a firmly established response strategy to an allocentric
                      place strategy. Rather, and in line with previous research,
                      age-related deficits in allocentric processing result in
                      shifts in preferred navigation strategies and an overall
                      bias for response strategies. The specific preference for a
                      beacon strategy is discussed in the context of a possible
                      dissociation between beacon-based and associative-cue-based
                      response learning in the striatum, with the latter being
                      more sensitive to age-related changes.},
      keywords     = {Adaptation, Psychological: physiology / Adult / Aged /
                      Aging / Association Learning / Bias / Cues / Female / Humans
                      / Male / Reaction Time: physiology / Spatial Behavior:
                      physiology / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23554482},
      pmc          = {pmc:PMC6618910},
      doi          = {10.1523/JNEUROSCI.0717-12.2013},
      url          = {https://pub.dzne.de/record/136867},
}