guest ::
| Home > Publications Database > Cell-to-cell propagation of infectious cytosolic protein aggregates. > print |
| Home > Publications Database > Cell-to-cell propagation of infectious cytosolic protein aggregates. > print |
| 001 | 136874 | ||
| 005 | 20240321220141.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1217321110 |2 doi |
| 024 | 7 | _ | |a pmid:23509289 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC3625284 |2 pmc |
| 024 | 7 | _ | |a 0027-8424 |2 ISSN |
| 024 | 7 | _ | |a 1091-6490 |2 ISSN |
| 024 | 7 | _ | |a altmetric:1317799 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-03196 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Hofmann, Julia P |0 P:(DE-2719)2630357 |b 0 |e First author |
| 245 | _ | _ | |a Cell-to-cell propagation of infectious cytosolic protein aggregates. |
| 260 | _ | _ | |a Washington, DC |c 2013 |b National Acad. of Sciences |
| 264 | _ | 1 | |3 online |2 Crossref |b Proceedings of the National Academy of Sciences |c 2013-03-18 |
| 264 | _ | 1 | |3 print |2 Crossref |b Proceedings of the National Academy of Sciences |c 2013-04-09 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1684226133_1958 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Prions are self-templating protein conformers that replicate by recruitment and conversion of homotypic proteins into growing protein aggregates. Originally identified as causative agents of transmissible spongiform encephalopathies, increasing evidence now suggests that prion-like phenomena are more common in nature than previously anticipated. In contrast to fungal prions that replicate in the cytoplasm, propagation of mammalian prions derived from the precursor protein PrP is confined to the cell membrane or endocytic vesicles. Here we demonstrate that cytosolic protein aggregates can also behave as infectious entities in mammalian cells. When expressed in the mammalian cytosol, protein aggregates derived from the prion domain NM of yeast translation termination factor Sup35 persistently propagate and invade neighboring cells, thereby inducing a self-perpetuating aggregation state of NM. Cell contact is required for efficient infection. Aggregates can also be induced in primary astrocytes, neurons, and organotypic cultures, demonstrating that this phenomenon is not specific to immortalized cells. Our data have important implications for understanding prion-like phenomena of protein aggregates associated with human diseases and for the growing number of amyloidogenic proteins discovered in mammals. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Peptide Termination Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Prions |2 NLM Chemicals |
| 650 | _ | 7 | |a SUP35 protein, S cerevisiae |2 NLM Chemicals |
| 650 | _ | 7 | |a Saccharomyces cerevisiae Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Green Fluorescent Proteins |0 147336-22-9 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: cytology |2 MeSH |
| 650 | _ | 2 | |a Cell Communication |2 MeSH |
| 650 | _ | 2 | |a Coculture Techniques |2 MeSH |
| 650 | _ | 2 | |a Cytoplasm: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cytosol: metabolism |2 MeSH |
| 650 | _ | 2 | |a Green Fluorescent Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Microscopy, Confocal |2 MeSH |
| 650 | _ | 2 | |a Peptide Termination Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Prion Diseases |2 MeSH |
| 650 | _ | 2 | |a Prions: metabolism |2 MeSH |
| 650 | _ | 2 | |a Protein Conformation |2 MeSH |
| 650 | _ | 2 | |a Saccharomyces cerevisiae: metabolism |2 MeSH |
| 650 | _ | 2 | |a Saccharomyces cerevisiae Proteins: metabolism |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)LAT-20190308 |5 EXP:(DE-2719)LAT-20190308 |e Laboratory Automation Technologies (CRFS-LAT) / Bonn |x 0 |
| 700 | 1 | _ | |a Denner, Philip |0 P:(DE-2719)2810245 |b 1 |
| 700 | 1 | _ | |a Nussbaum-Krammer, Carmen |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Kuhn, Peer-Hendrik |0 P:(DE-2719)2810327 |b 3 |
| 700 | 1 | _ | |a Suhre, Michael H |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Scheibel, Thomas |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Lichtenthaler, Stefan F |0 P:(DE-2719)2181459 |b 6 |
| 700 | 1 | _ | |a Schätzl, Hermann M |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Bano, Daniele |0 P:(DE-2719)2158358 |b 8 |
| 700 | 1 | _ | |a Vorberg, Ina M |0 P:(DE-2719)2481765 |b 9 |e Last author |
| 773 | 1 | 8 | |a 10.1073/pnas.1217321110 |b : Proceedings of the National Academy of Sciences, 2013-03-18 |n 15 |p 5951-5956 |3 journal-article |2 Crossref |t Proceedings of the National Academy of Sciences |v 110 |y 2013 |x 0027-8424 |
| 773 | _ | _ | |a 10.1073/pnas.1217321110 |g Vol. 110, no. 15, p. 5951 - 5956 |0 PERI:(DE-600)1461794-8 |n 15 |q 110:15<5951 - 5956 |p 5951-5956 |t Proceedings of the National Academy of Sciences of the United States of America |v 110 |y 2013 |x 0027-8424 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625284 |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:136874 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2630357 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2810245 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2810327 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2181459 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)2158358 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)2481765 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 1 |
| 914 | 1 | _ | |y 2013 |
| 915 | _ | _ | |a National-Konsortium |0 StatID:(DE-HGF)0430 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b P NATL ACAD SCI USA : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b P NATL ACAD SCI USA : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1110006 |k AG Lichtenthaler |l Neuroproteomics |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013003 |k AG Bano |l Aging and neurodegeneration |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1013032 |k AG Salomoni |l Nuclear function in CNS pathophysiology |x 2 |
| 920 | 1 | _ | |0 I:(DE-2719)1013004 |k AG Vorberg |l Prion Cell Biology |x 3 |
| 920 | 1 | _ | |0 I:(DE-2719)1040190 |k LAT |l Laboratory Automation Technologies (LAT) |x 4 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1110006 |
| 980 | _ | _ | |a I:(DE-2719)1013003 |
| 980 | _ | _ | |a I:(DE-2719)1013032 |
| 980 | _ | _ | |a I:(DE-2719)1013004 |
| 980 | _ | _ | |a I:(DE-2719)1040190 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.95.23.13363 |2 Crossref |o 10.1073/pnas.95.23.13363 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.7909170 |2 Crossref |o 10.1126/science.7909170 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrmicro1708 |2 Crossref |o 10.1038/nrmicro1708 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2009.02.044 |2 Crossref |o 10.1016/j.cell.2009.02.044 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.90.13.5959 |2 Crossref |o 10.1073/pnas.90.13.5959 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.97.22.11910 |2 Crossref |o 10.1073/pnas.97.22.11910 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1019368108 |2 Crossref |o 10.1073/pnas.1019368108 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.092205999 |2 Crossref |o 10.1073/pnas.092205999 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00401-011-0825-z |2 Crossref |o 10.1007/s00401-011-0825-z |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tins.2010.04.003 |2 Crossref |o 10.1016/j.tins.2010.04.003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3390/v5010374 |2 Crossref |o 10.3390/v5010374 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M808759200 |2 Crossref |o 10.1074/jbc.M808759200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.2009.06324.x |2 Crossref |o 10.1111/j.1471-4159.2009.06324.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0903691106 |2 Crossref |o 10.1073/pnas.0903691106 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncb1830 |2 Crossref |o 10.1038/ncb1830 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M110.209296 |2 Crossref |o 10.1074/jbc.M110.209296 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1017275108 |2 Crossref |o 10.1073/pnas.1017275108 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1096/fj.07-8733com |2 Crossref |o 10.1096/fj.07-8733com |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0811571106 |2 Crossref |o 10.1073/pnas.0811571106 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M402576200 |2 Crossref |o 10.1074/jbc.M402576200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature04922 |2 Crossref |o 10.1038/nature04922 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M307996200 |2 Crossref |o 10.1074/jbc.M307996200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00109-003-0464-5 |2 Crossref |o 10.1007/s00109-003-0464-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2010.11.050 |2 Crossref |o 10.1016/j.cell.2010.11.050 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.micro.56.013002.100603 |2 Crossref |o 10.1146/annurev.micro.56.013002.100603 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature02392 |2 Crossref |o 10.1038/nature02392 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature02391 |2 Crossref |o 10.1038/nature02391 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.biochem.78.082907.145410 |2 Crossref |o 10.1146/annurev.biochem.78.082907.145410 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/emboj.2009.392 |2 Crossref |o 10.1038/emboj.2009.392 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1110837 |2 Crossref |o 10.1126/science.1110837 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/JVI.02167-10 |2 Crossref |o 10.1128/JVI.02167-10 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0308413101 |2 Crossref |o 10.1073/pnas.0308413101 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0960-9822(02)00722-4 |2 Crossref |o 10.1016/S0960-9822(02)00722-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncb1841 |2 Crossref |o 10.1038/ncb1841 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncb1544 |2 Crossref |o 10.1038/ncb1544 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1209397109 |2 Crossref |o 10.1073/pnas.1209397109 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1080115 |2 Crossref |o 10.1126/science.1080115 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/ana.22615 |2 Crossref |o 10.1002/ana.22615 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.1993.tb09823.x |2 Crossref |o 10.1111/j.1471-4159.1993.tb09823.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0692-05.2005 |2 Crossref |o 10.1523/JNEUROSCI.0692-05.2005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M111.277061 |2 Crossref |o 10.1074/jbc.M111.277061 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0708372104 |2 Crossref |o 10.1073/pnas.0708372104 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.7754373 |2 Crossref |o 10.1126/science.7754373 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pbio.0040417 |2 Crossref |o 10.1371/journal.pbio.0040417 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2012.06.019 |2 Crossref |o 10.1016/j.cell.2012.06.019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1173155 |2 Crossref |o 10.1126/science.1173155 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pbio.0040006 |2 Crossref |o 10.1371/journal.pbio.0040006 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2011.06.041 |2 Crossref |o 10.1016/j.cell.2011.06.041 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.brainres.2012.01.016 |2 Crossref |o 10.1016/j.brainres.2012.01.016 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|