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000136892 0247_ $$2doi$$a10.1523/JNEUROSCI.3372-12.2013
000136892 0247_ $$2pmid$$apmid:23637177
000136892 0247_ $$2pmc$$apmc:PMC6618983
000136892 0247_ $$2ISSN$$a0270-6474
000136892 0247_ $$2ISSN$$a1529-2401
000136892 0247_ $$2altmetric$$aaltmetric:41312032
000136892 037__ $$aDZNE-2020-03214
000136892 041__ $$aEnglish
000136892 082__ $$a610
000136892 1001_ $$0P:(DE-HGF)0$$aFleck, Daniel$$b0
000136892 245__ $$aDual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
000136892 260__ $$aWashington, DC$$bSoc.57413$$c2013
000136892 264_1 $$2Crossref$$3online$$bSociety for Neuroscience$$c2013-05-01
000136892 264_1 $$2Crossref$$3print$$bSociety for Neuroscience$$c2013-05-01
000136892 3367_ $$2DRIVER$$aarticle
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000136892 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1589983214_10887
000136892 3367_ $$2BibTeX$$aARTICLE
000136892 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136892 3367_ $$00$$2EndNote$$aJournal Article
000136892 520__ $$aProteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and BACE1. These proteases are major therapeutic targets for the prevention of Alzheimer's disease because they are also involved in the proteolytic generation of the neurotoxic amyloid β-peptide. Identification and functional investigation of their physiological substrates is therefore of greatest importance in preventing unwanted side effects. Here we investigated proteolytic processing of NRG1 type III and demonstrate that the ectodomain can be cleaved by three different sheddases, namely ADAM10, ADAM17, and BACE1. Surprisingly, we not only found cleavage by ADAM10, ADAM17, and BACE1 C-terminal to the epidermal growth factor (EGF)-like domain, which is believed to play a pivotal role in signaling, but also additional cleavage sites for ADAM17 and BACE1 N-terminal to that domain. Proteolytic processing at N- and C-terminal sites of the EGF-like domain results in the secretion of this domain from NRG1 type III. The soluble EGF-like domain is functionally active and stimulates ErbB3 signaling in tissue culture assays. Moreover, the soluble EGF-like domain is capable of rescuing hypomyelination in a zebrafish mutant lacking BACE1. Our data suggest that NRG1 type III-dependent myelination is not only controlled by membrane-retained NRG1 type III, but also in a paracrine manner via proteolytic liberation of the EGF-like domain.
000136892 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000136892 542__ $$2Crossref$$i2013-11-01$$uhttps://creativecommons.org/licenses/by-nc-sa/4.0/
000136892 588__ $$aDataset connected to CrossRef, PubMed,
000136892 650_7 $$2NLM Chemicals$$aNRG3 protein, human
000136892 650_7 $$2NLM Chemicals$$aNeuregulins
000136892 650_7 $$2NLM Chemicals$$aRNA, Messenger
000136892 650_7 $$2NLM Chemicals$$aRNA, Small Interfering
000136892 650_7 $$062229-50-9$$2NLM Chemicals$$aEpidermal Growth Factor
000136892 650_7 $$0EC 3.4.-$$2NLM Chemicals$$aAmyloid Precursor Protein Secretases
000136892 650_7 $$0EC 3.4.23.-$$2NLM Chemicals$$aAspartic Acid Endopeptidases
000136892 650_7 $$0EC 3.4.23.46$$2NLM Chemicals$$aBACE1 protein, human
000136892 650_7 $$0EC 3.4.24.-$$2NLM Chemicals$$aADAM Proteins
000136892 650_7 $$0EC 3.4.24.86$$2NLM Chemicals$$aADAM17 Protein
000136892 650_7 $$0EC 3.4.24.86$$2NLM Chemicals$$aADAM17 protein, human
000136892 650_7 $$0EC 3.4.24.86$$2NLM Chemicals$$aAdam17 protein, rat
000136892 650_2 $$2MeSH$$aADAM Proteins: metabolism
000136892 650_2 $$2MeSH$$aADAM17 Protein
000136892 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: metabolism
000136892 650_2 $$2MeSH$$aAnimals
000136892 650_2 $$2MeSH$$aAspartic Acid Endopeptidases: metabolism
000136892 650_2 $$2MeSH$$aCell Membrane: metabolism
000136892 650_2 $$2MeSH$$aCells, Cultured
000136892 650_2 $$2MeSH$$aCricetinae
000136892 650_2 $$2MeSH$$aCricetulus
000136892 650_2 $$2MeSH$$aEmbryo, Mammalian
000136892 650_2 $$2MeSH$$aEpidermal Growth Factor: analogs & derivatives
000136892 650_2 $$2MeSH$$aEpidermal Growth Factor: chemistry
000136892 650_2 $$2MeSH$$aHumans
000136892 650_2 $$2MeSH$$aImmunoprecipitation
000136892 650_2 $$2MeSH$$aNeuregulins: genetics
000136892 650_2 $$2MeSH$$aNeuregulins: metabolism
000136892 650_2 $$2MeSH$$aNeurons
000136892 650_2 $$2MeSH$$aParacrine Communication: physiology
000136892 650_2 $$2MeSH$$aPhosphorylation
000136892 650_2 $$2MeSH$$aProteolysis
000136892 650_2 $$2MeSH$$aRNA, Messenger: administration & dosage
000136892 650_2 $$2MeSH$$aRNA, Messenger: metabolism
000136892 650_2 $$2MeSH$$aRNA, Small Interfering: metabolism
000136892 650_2 $$2MeSH$$aRats
000136892 650_2 $$2MeSH$$aRats, Sprague-Dawley
000136892 650_2 $$2MeSH$$aSchwann Cells
000136892 650_2 $$2MeSH$$aTransfection
000136892 650_2 $$2MeSH$$aZebrafish
000136892 7001_ $$0P:(DE-2719)9000319$$avan Bebber, Frauke$$b1
000136892 7001_ $$0P:(DE-2719)2340744$$aColombo, Alessio$$b2
000136892 7001_ $$aGalante, Chiara$$b3
000136892 7001_ $$0P:(DE-2719)2551184$$aSchwenk, Benjamin M$$b4
000136892 7001_ $$aRabe, Linnea$$b5
000136892 7001_ $$aHampel, Heike$$b6
000136892 7001_ $$aNovak, Bozidar$$b7
000136892 7001_ $$0P:(DE-HGF)0$$aKremmer, Elisabeth$$b8
000136892 7001_ $$0P:(DE-2719)2442036$$aTahirovic, Sabina$$b9
000136892 7001_ $$0P:(DE-2719)2231621$$aEdbauer, Dieter$$b10
000136892 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan F$$b11
000136892 7001_ $$0P:(DE-2719)2241638$$aSchmid, Bettina$$b12
000136892 7001_ $$0P:(DE-HGF)0$$aWillem, Michael$$b13
000136892 7001_ $$0P:(DE-2719)2202037$$aHaass, Christian$$b14$$eLast author
000136892 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.3372-12.2013$$bSociety for Neuroscience$$d2013-05-01$$n18$$p7856-7869$$tThe Journal of Neuroscience$$v33$$x0270-6474$$y2013
000136892 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.3372-12.2013$$gVol. 33, no. 18, p. 7856 - 7869$$n18$$p7856-7869$$q33:18<7856 - 7869$$tThe journal of neuroscience$$v33$$x0270-6474$$y2013
000136892 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618983
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000136892 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000136892 9141_ $$y2013
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000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200212085
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn1342
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/glia.20753
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/385729a0
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.yexcr.2008.10.011
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2008.06.028
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0092-8674(00)80675-3
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1042/BJ20090549
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.8424174
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M003202200
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0605-10.2010
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/360672a0
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0896-6273(95)90323-2
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrneurol.2009.218
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1559-0275-8-9
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.139.6.1495
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1023/B:NEUR.0000020614.83883.be
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/sj.emboj.7600061
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ydbio.2005.05.004
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn1797
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.08-106666
000136892 999C5 $$1Karey$$2Crossref$$oKarey 1988$$y1988
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/aja.1002030302
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0092-8674(86)90841-X
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/physiol.00028.2010
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.2849
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1471-4159.2011.07248.x
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2174/1386207053258488
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M111.251538
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn2392
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1095862
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.conb.2009.08.006
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1006/mcne.2000.0896
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/glia.21260
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.semcdb.2010.08.008
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/cdf541
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/embor.2012.90
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/dev.068072
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1080/08977190600634373
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/embo-reports/kve180
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M007913200
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1681-09.2010
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2005.08.017
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/emboj.2012.42
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/jnc.12198
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/alzrt82
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/glia.21255
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M005700200
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M601542200
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1132341
000136892 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(00)80873-9