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000136914 0247_ $$2doi$$a10.1038/jid.2013.43
000136914 0247_ $$2pmid$$apmid:23358095
000136914 0247_ $$2ISSN$$a0022-202X
000136914 0247_ $$2ISSN$$a1523-1747
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000136914 037__ $$aDZNE-2020-03236
000136914 041__ $$aEnglish
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000136914 1001_ $$aHeilmann, Stefanie$$b0
000136914 245__ $$aAndrogenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.
000136914 260__ $$aAmsterdam$$bElsevier$$c2013
000136914 264_1 $$2Crossref$$3print$$bElsevier BV$$c2013-06-01
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000136914 520__ $$aThe pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits identification. Furthermore, the understanding of the pathophysiology of AGA is incomplete, and each newly associated locus may provide novel insights into contributing biological pathways. The aim of this study was to identify unknown AGA risk loci by replicating SNPs at the 12 genomic loci that showed suggestive association (5 × 10−8<P<10−5) with AGA in a recent meta-analysis. We analyzed a replication set comprising 2,759 cases and 2,661 controls of European descent to confirm the association with AGA at these loci. Combined analysis of the replication and the meta-analysis data identified four genome-wide significant risk loci for AGA on chromosomes 2q35, 3q25.1, 5q33.3, and 12p12.1. The strongest association signal was obtained for rs7349332 (P=3.55 × 10−15) on chr2q35, which is located intronically in WNT10A. Expression studies in human hair follicle tissue suggest that WNT10A has a functional role in AGA etiology. Thus, our study provides genetic evidence supporting an involvement of WNT signaling in AGA development.
000136914 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
000136914 542__ $$2Crossref$$i2013-06-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000136914 542__ $$2Crossref$$i2015-12-02$$uhttps://www.elsevier.com/open-access/userlicense/1.0/
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000136914 650_7 $$2NLM Chemicals$$aFZD10 protein, human
000136914 650_7 $$2NLM Chemicals$$aFrizzled Receptors
000136914 650_7 $$2NLM Chemicals$$aWNT10A protein, human
000136914 650_7 $$2NLM Chemicals$$aWNT3 protein, human
000136914 650_7 $$2NLM Chemicals$$aWNT6 protein, human
000136914 650_7 $$2NLM Chemicals$$aWnt Proteins
000136914 650_7 $$2NLM Chemicals$$aWnt3 Protein
000136914 650_7 $$0EC 1.14.15.15$$2NLM Chemicals$$aCYP27A1 protein, human
000136914 650_7 $$0EC 1.14.15.15$$2NLM Chemicals$$aCholestanetriol 26-Monooxygenase
000136914 650_2 $$2MeSH$$aAdult
000136914 650_2 $$2MeSH$$aAlopecia: epidemiology
000136914 650_2 $$2MeSH$$aAlopecia: etiology
000136914 650_2 $$2MeSH$$aAlopecia: genetics
000136914 650_2 $$2MeSH$$aAlopecia: metabolism
000136914 650_2 $$2MeSH$$aCholestanetriol 26-Monooxygenase: genetics
000136914 650_2 $$2MeSH$$aChromosomes, Human, Pair 12
000136914 650_2 $$2MeSH$$aChromosomes, Human, Pair 2
000136914 650_2 $$2MeSH$$aChromosomes, Human, Pair 3
000136914 650_2 $$2MeSH$$aChromosomes, Human, Pair 5
000136914 650_2 $$2MeSH$$aEuropean Continental Ancestry Group: genetics
000136914 650_2 $$2MeSH$$aEuropean Continental Ancestry Group: statistics & numerical data
000136914 650_2 $$2MeSH$$aFrizzled Receptors: genetics
000136914 650_2 $$2MeSH$$aGenetic Predisposition to Disease: epidemiology
000136914 650_2 $$2MeSH$$aGenetic Predisposition to Disease: genetics
000136914 650_2 $$2MeSH$$aGenome-Wide Association Study
000136914 650_2 $$2MeSH$$aHumans
000136914 650_2 $$2MeSH$$aMale
000136914 650_2 $$2MeSH$$aMiddle Aged
000136914 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000136914 650_2 $$2MeSH$$aRisk Factors
000136914 650_2 $$2MeSH$$aWnt Proteins: genetics
000136914 650_2 $$2MeSH$$aWnt Signaling Pathway: physiology
000136914 650_2 $$2MeSH$$aWnt3 Protein: genetics
000136914 7001_ $$aKiefer, Amy K$$b1
000136914 7001_ $$aFricker, Nadine$$b2
000136914 7001_ $$0P:(DE-2719)2740473$$aDrichel, Dmitriy$$b3$$udzne
000136914 7001_ $$aHillmer, Axel M$$b4
000136914 7001_ $$0P:(DE-2719)2802016$$aHerold, Christine$$b5$$udzne
000136914 7001_ $$aTung, Joyce Y$$b6
000136914 7001_ $$aEriksson, Nicholas$$b7
000136914 7001_ $$aRedler, Silke$$b8
000136914 7001_ $$aBetz, Regina C$$b9
000136914 7001_ $$aLi, Rui$$b10
000136914 7001_ $$aKárason, Ari$$b11
000136914 7001_ $$aNyholt, Dale R$$b12
000136914 7001_ $$aSong, Kijoung$$b13
000136914 7001_ $$aVermeulen, Sita H$$b14
000136914 7001_ $$aKanoni, Stavroula$$b15
000136914 7001_ $$aDedoussis, George$$b16
000136914 7001_ $$aMartin, Nicholas G$$b17
000136914 7001_ $$aKiemeney, Lambertus A$$b18
000136914 7001_ $$aMooser, Vincent$$b19
000136914 7001_ $$aStefansson, Kari$$b20
000136914 7001_ $$aRichards, J Brent$$b21
000136914 7001_ $$0P:(DE-2719)2501867$$aBecker, Tim$$b22$$udzne
000136914 7001_ $$aBrockschmidt, Felix F$$b23
000136914 7001_ $$aHinds, David A$$b24
000136914 7001_ $$0P:(DE-HGF)0$$aNöthen, Markus M$$b25$$eCorresponding author
000136914 77318 $$2Crossref$$3journal-article$$a10.1038/jid.2013.43$$b : Elsevier BV, 2013-06-01$$n6$$p1489-1496$$tJournal of Investigative Dermatology$$v133$$x0022-202X$$y2013
000136914 773__ $$0PERI:(DE-600)2006902-9$$a10.1038/jid.2013.43$$gVol. 133, no. 6, p. 1489 - 1496$$n6$$p1489-1496$$q133:6<1489 - 1496$$tThe journal of investigative dermatology$$v133$$x0022-202X$$y2013
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