001     136914
005     20240719165309.0
024 7 _ |a 10.1038/jid.2013.43
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024 7 _ |a 1523-1747
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037 _ _ |a DZNE-2020-03236
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Heilmann, Stefanie
|b 0
245 _ _ |a Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.
260 _ _ |a Amsterdam
|c 2013
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2013-06-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits identification. Furthermore, the understanding of the pathophysiology of AGA is incomplete, and each newly associated locus may provide novel insights into contributing biological pathways. The aim of this study was to identify unknown AGA risk loci by replicating SNPs at the 12 genomic loci that showed suggestive association (5 × 10−8
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
|0 G:(DE-HGF)POF3-345
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|f POF III
|x 0
542 _ _ |i 2013-06-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2015-12-02
|2 Crossref
|u https://www.elsevier.com/open-access/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a FZD10 protein, human
|2 NLM Chemicals
650 _ 7 |a Frizzled Receptors
|2 NLM Chemicals
650 _ 7 |a WNT10A protein, human
|2 NLM Chemicals
650 _ 7 |a WNT3 protein, human
|2 NLM Chemicals
650 _ 7 |a WNT6 protein, human
|2 NLM Chemicals
650 _ 7 |a Wnt Proteins
|2 NLM Chemicals
650 _ 7 |a Wnt3 Protein
|2 NLM Chemicals
650 _ 7 |a CYP27A1 protein, human
|0 EC 1.14.15.15
|2 NLM Chemicals
650 _ 7 |a Cholestanetriol 26-Monooxygenase
|0 EC 1.14.15.15
|2 NLM Chemicals
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Alopecia: epidemiology
|2 MeSH
650 _ 2 |a Alopecia: etiology
|2 MeSH
650 _ 2 |a Alopecia: genetics
|2 MeSH
650 _ 2 |a Alopecia: metabolism
|2 MeSH
650 _ 2 |a Cholestanetriol 26-Monooxygenase: genetics
|2 MeSH
650 _ 2 |a Chromosomes, Human, Pair 12
|2 MeSH
650 _ 2 |a Chromosomes, Human, Pair 2
|2 MeSH
650 _ 2 |a Chromosomes, Human, Pair 3
|2 MeSH
650 _ 2 |a Chromosomes, Human, Pair 5
|2 MeSH
650 _ 2 |a European Continental Ancestry Group: genetics
|2 MeSH
650 _ 2 |a European Continental Ancestry Group: statistics & numerical data
|2 MeSH
650 _ 2 |a Frizzled Receptors: genetics
|2 MeSH
650 _ 2 |a Genetic Predisposition to Disease: epidemiology
|2 MeSH
650 _ 2 |a Genetic Predisposition to Disease: genetics
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide: genetics
|2 MeSH
650 _ 2 |a Risk Factors
|2 MeSH
650 _ 2 |a Wnt Proteins: genetics
|2 MeSH
650 _ 2 |a Wnt Signaling Pathway: physiology
|2 MeSH
650 _ 2 |a Wnt3 Protein: genetics
|2 MeSH
700 1 _ |a Kiefer, Amy K
|b 1
700 1 _ |a Fricker, Nadine
|b 2
700 1 _ |a Drichel, Dmitriy
|0 P:(DE-2719)2740473
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|u dzne
700 1 _ |a Hillmer, Axel M
|b 4
700 1 _ |a Herold, Christine
|0 P:(DE-2719)2802016
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|u dzne
700 1 _ |a Tung, Joyce Y
|b 6
700 1 _ |a Eriksson, Nicholas
|b 7
700 1 _ |a Redler, Silke
|b 8
700 1 _ |a Betz, Regina C
|b 9
700 1 _ |a Li, Rui
|b 10
700 1 _ |a Kárason, Ari
|b 11
700 1 _ |a Nyholt, Dale R
|b 12
700 1 _ |a Song, Kijoung
|b 13
700 1 _ |a Vermeulen, Sita H
|b 14
700 1 _ |a Kanoni, Stavroula
|b 15
700 1 _ |a Dedoussis, George
|b 16
700 1 _ |a Martin, Nicholas G
|b 17
700 1 _ |a Kiemeney, Lambertus A
|b 18
700 1 _ |a Mooser, Vincent
|b 19
700 1 _ |a Stefansson, Kari
|b 20
700 1 _ |a Richards, J Brent
|b 21
700 1 _ |a Becker, Tim
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700 1 _ |a Brockschmidt, Felix F
|b 23
700 1 _ |a Hinds, David A
|b 24
700 1 _ |a Nöthen, Markus M
|0 P:(DE-HGF)0
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|e Corresponding author
773 1 8 |a 10.1038/jid.2013.43
|b : Elsevier BV, 2013-06-01
|n 6
|p 1489-1496
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|t Journal of Investigative Dermatology
|v 133
|y 2013
|x 0022-202X
773 _ _ |a 10.1038/jid.2013.43
|g Vol. 133, no. 6, p. 1489 - 1496
|0 PERI:(DE-600)2006902-9
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|q 133:6<1489 - 1496
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|t The journal of investigative dermatology
|v 133
|y 2013
|x 0022-202X
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Marc 21