TY  - JOUR
AU  - Latz, Eicke
AU  - Xiao, T Sam
AU  - Stutz, Andrea
TI  - Activation and regulation of the inflammasomes.
JO  - Nature reviews / Immunology
VL  - 13
IS  - 6
SN  - 1474-1733
CY  - London
PB  - Nature Publ. Group
M1  - DZNE-2020-03245
SP  - 397-411
PY  - 2013
AB  - Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
KW  - Autophagy: immunology
KW  - Carrier Proteins: immunology
KW  - Carrier Proteins: metabolism
KW  - Humans
KW  - Inflammasomes: immunology
KW  - Inflammasomes: metabolism
KW  - Inflammation Mediators: immunology
KW  - Inflammation Mediators: metabolism
KW  - Interleukin-18: immunology
KW  - Interleukin-18: metabolism
KW  - Interleukin-1beta: immunology
KW  - Interleukin-1beta: metabolism
KW  - Models, Immunological
KW  - NLR Family, Pyrin Domain-Containing 3 Protein
KW  - Receptors, Interleukin-1: immunology
KW  - Receptors, Interleukin-1: metabolism
KW  - Signal Transduction: immunology
KW  - Carrier Proteins (NLM Chemicals)
KW  - Inflammasomes (NLM Chemicals)
KW  - Inflammation Mediators (NLM Chemicals)
KW  - Interleukin-18 (NLM Chemicals)
KW  - Interleukin-1beta (NLM Chemicals)
KW  - NLR Family, Pyrin Domain-Containing 3 Protein (NLM Chemicals)
KW  - NLRP3 protein, human (NLM Chemicals)
KW  - Receptors, Interleukin-1 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:23702978
C2  - pmc:PMC3807999
DO  - DOI:10.1038/nri3452
UR  - https://pub.dzne.de/record/136923
ER  -