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@ARTICLE{Latz:136923,
      author       = {Latz, Eicke and Xiao, T Sam and Stutz, Andrea},
      title        = {{A}ctivation and regulation of the inflammasomes.},
      journal      = {Nature reviews / Immunology},
      volume       = {13},
      number       = {6},
      issn         = {1474-1733},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2020-03245},
      pages        = {397-411},
      year         = {2013},
      abstract     = {Inflammasomes are key signalling platforms that detect
                      pathogenic microorganisms and sterile stressors, and that
                      activate the highly pro-inflammatory cytokines
                      interleukin-1β (IL-1β) and IL-18. In this Review, we
                      discuss the complex regulatory mechanisms that facilitate a
                      balanced but effective inflammasome-mediated immune
                      response, and we highlight the similarities to another
                      molecular signalling platform - the apoptosome - that
                      monitors cellular health. Extracellular regulatory
                      mechanisms are discussed, as well as the intracellular
                      control of inflammasome assembly, for example, via ion
                      fluxes, free radicals and autophagy.},
      subtyp        = {Review Article},
      keywords     = {Autophagy: immunology / Carrier Proteins: immunology /
                      Carrier Proteins: metabolism / Humans / Inflammasomes:
                      immunology / Inflammasomes: metabolism / Inflammation
                      Mediators: immunology / Inflammation Mediators: metabolism /
                      Interleukin-18: immunology / Interleukin-18: metabolism /
                      Interleukin-1beta: immunology / Interleukin-1beta:
                      metabolism / Models, Immunological / NLR Family, Pyrin
                      Domain-Containing 3 Protein / Receptors, Interleukin-1:
                      immunology / Receptors, Interleukin-1: metabolism / Signal
                      Transduction: immunology / Carrier Proteins (NLM Chemicals)
                      / Inflammasomes (NLM Chemicals) / Inflammation Mediators
                      (NLM Chemicals) / Interleukin-18 (NLM Chemicals) /
                      Interleukin-1beta (NLM Chemicals) / NLR Family, Pyrin
                      Domain-Containing 3 Protein (NLM Chemicals) / NLRP3 protein,
                      human (NLM Chemicals) / Receptors, Interleukin-1 (NLM
                      Chemicals)},
      cin          = {AG Latz},
      ddc          = {570},
      cid          = {I:(DE-2719)1013024},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23702978},
      pmc          = {pmc:PMC3807999},
      doi          = {10.1038/nri3452},
      url          = {https://pub.dzne.de/record/136923},
}