Home > Publications Database > Activation and regulation of the inflammasomes. > print

001     136923
005     20250318152217.0
024 7 _ |a 10.1038/nri3452
|2 doi
024 7 _ |a pmid:23702978
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024 7 _ |a pmc:PMC3807999
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024 7 _ |a 1474-1733
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024 7 _ |a 1474-1741
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037 _ _ |a DZNE-2020-03245
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Latz, Eicke
|0 P:(DE-2719)2000062
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|e First author
|u dzne
245 _ _ |a Activation and regulation of the inflammasomes.
260 _ _ |a London
|c 2013
|b Nature Publ. Group
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2013-05-24
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2013-06-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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542 _ _ |i 2013-05-24
|2 Crossref
|u http://www.springer.com/tdm
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Carrier Proteins
|2 NLM Chemicals
650 _ 7 |a Inflammasomes
|2 NLM Chemicals
650 _ 7 |a Inflammation Mediators
|2 NLM Chemicals
650 _ 7 |a Interleukin-18
|2 NLM Chemicals
650 _ 7 |a Interleukin-1beta
|2 NLM Chemicals
650 _ 7 |a NLR Family, Pyrin Domain-Containing 3 Protein
|2 NLM Chemicals
650 _ 7 |a NLRP3 protein, human
|2 NLM Chemicals
650 _ 7 |a Receptors, Interleukin-1
|2 NLM Chemicals
650 _ 2 |a Autophagy: immunology
|2 MeSH
650 _ 2 |a Carrier Proteins: immunology
|2 MeSH
650 _ 2 |a Carrier Proteins: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Inflammasomes: immunology
|2 MeSH
650 _ 2 |a Inflammasomes: metabolism
|2 MeSH
650 _ 2 |a Inflammation Mediators: immunology
|2 MeSH
650 _ 2 |a Inflammation Mediators: metabolism
|2 MeSH
650 _ 2 |a Interleukin-18: immunology
|2 MeSH
650 _ 2 |a Interleukin-18: metabolism
|2 MeSH
650 _ 2 |a Interleukin-1beta: immunology
|2 MeSH
650 _ 2 |a Interleukin-1beta: metabolism
|2 MeSH
650 _ 2 |a Models, Immunological
|2 MeSH
650 _ 2 |a NLR Family, Pyrin Domain-Containing 3 Protein
|2 MeSH
650 _ 2 |a Receptors, Interleukin-1: immunology
|2 MeSH
650 _ 2 |a Receptors, Interleukin-1: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction: immunology
|2 MeSH
700 1 _ |a Xiao, T Sam
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Stutz, Andrea
|0 P:(DE-HGF)0
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773 1 8 |a 10.1038/nri3452
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|n 6
|p 397-411
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|t Nature Reviews Immunology
|v 13
|y 2013
|x 1474-1733
773 _ _ |a 10.1038/nri3452
|g Vol. 13, no. 6, p. 397 - 411
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|t Nature reviews / Immunology
|v 13
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856 7 _ |2 Pubmed Central
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856 4 _ |u https://pub.dzne.de/record/136923/files/DZNE-2020-03245_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/136923/files/DZNE-2020-03245_Restricted.pdf?subformat=pdfa
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21