guest ::
| Home > Publications Database > The intramembrane protease SPPL2A is critical for tooth enamel formation. > print |
| Home > Publications Database > The intramembrane protease SPPL2A is critical for tooth enamel formation. > print |
| 001 | 136944 | ||
| 005 | 20250411125256.0 | ||
| 024 | 7 | _ | |a 10.1002/jbmr.1895 |2 doi |
| 024 | 7 | _ | |a pmid:23426979 |2 pmid |
| 024 | 7 | _ | |a 0884-0431 |2 ISSN |
| 024 | 7 | _ | |a 1523-4681 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-03266 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bronckers, Antonius L J J |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a The intramembrane protease SPPL2A is critical for tooth enamel formation. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2013 |b Wiley |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2013-06-18 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2013-07-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744368741_23681 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Intramembrane proteases are critically involved in signal transduction and membrane protein turnover. Signal-peptide-peptidase-like 2a (SPPL2A), a presenilin-homologue residing in lysosomes/late endosomes, cleaves type II-oriented transmembrane proteins. We recently identified SPPL2A as the enzyme controlling turnover and functions of the invariant chain (CD74) of the major histocompatibility complex II (MHCII) and demonstrated critical importance of this process for B cell development. Surprisingly, we found that SPPL2A is critical for formation of dental enamel. In Sppl2a knockout mice, enamel of the erupted incisors was chalky white and rapidly eroded after eruption. SPPL2A was found to be expressed in enamel epithelium during secretory and maturation stage amelogenesis. Mineral content of enamel in Sppl2a⁻/⁻ incisors was inhomogeneous and reduced by ∼20% compared to wild-type mice with the most pronounced reduction at the mesial side. Frequently, disruption of the enamel layer and localized detachment of the most superficial enamel layer was observed in the knockout incisors leading to an uneven enamel surface. In Sppl2a null mice, morphology and function of secretory stage ameloblasts were not noticeably different from that of wild-type mice. However, maturation stage ameloblasts showed reduced height and a characteristic undulation of the ameloblast layer with localized adherence of the cells to the outer enamel. This was reflected in a delayed and incomplete resorption of the proteinaceous enamel matrix. Thus, we conclude that intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts. Because modulation of SPPL2A activity appears to be an attractive therapeutic target to deplete B cells and treat autoimmunity, interference with tooth enamel formation should be investigated as a possible adverse effect of pharmacological SPPL2A inhibitors in humans. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-09-01 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antigens, Differentiation, B-Lymphocyte |2 NLM Chemicals |
| 650 | _ | 7 | |a Histocompatibility Antigens Class II |2 NLM Chemicals |
| 650 | _ | 7 | |a Membrane Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a invariant chain |2 NLM Chemicals |
| 650 | _ | 7 | |a Aspartic Acid Endopeptidases |0 EC 3.4.23.- |2 NLM Chemicals |
| 650 | _ | 7 | |a SPPL2a protein, mouse |0 EC 3.4.23.- |2 NLM Chemicals |
| 650 | _ | 2 | |a Ameloblasts: enzymology |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Antigens, Differentiation, B-Lymphocyte: genetics |2 MeSH |
| 650 | _ | 2 | |a Antigens, Differentiation, B-Lymphocyte: metabolism |2 MeSH |
| 650 | _ | 2 | |a Aspartic Acid Endopeptidases: genetics |2 MeSH |
| 650 | _ | 2 | |a Aspartic Acid Endopeptidases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Dental Enamel: enzymology |2 MeSH |
| 650 | _ | 2 | |a Dental Enamel: growth & development |2 MeSH |
| 650 | _ | 2 | |a Histocompatibility Antigens Class II: genetics |2 MeSH |
| 650 | _ | 2 | |a Histocompatibility Antigens Class II: metabolism |2 MeSH |
| 650 | _ | 2 | |a Incisor: enzymology |2 MeSH |
| 650 | _ | 2 | |a Incisor: growth & development |2 MeSH |
| 650 | _ | 2 | |a Membrane Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Membrane Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a Proteolysis |2 MeSH |
| 700 | 1 | _ | |a Gueneli, Nur |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Lüllmann-Rauch, Renate |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Schneppenheim, Janna |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Moraru, Andreea P |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Himmerkus, Nina |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Bervoets, Theodore J |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Fluhrer, Regina |0 P:(DE-2719)2000007 |b 7 |u dzne |
| 700 | 1 | _ | |a Everts, Vincent |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Saftig, Paul |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Schröder, Bernd |0 P:(DE-HGF)0 |b 10 |
| 773 | 1 | 8 | |a 10.1002/jbmr.1895 |b : Wiley, 2013-06-18 |n 7 |p 1622-1630 |3 journal-article |2 Crossref |t Journal of Bone and Mineral Research |v 28 |y 2013 |x 0884-0431 |
| 773 | _ | _ | |a 10.1002/jbmr.1895 |g Vol. 28, no. 7, p. 1622 - 1630 |0 PERI:(DE-600)2008867-X |n 7 |q 28:7<1622 - 1630 |p 1622-1630 |t Journal of bone and mineral research |v 28 |y 2013 |x 0884-0431 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136944/files/DZNE-2020-03266_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136944/files/DZNE-2020-03266_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:136944 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2000007 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2013 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J BONE MINER RES : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b J BONE MINER RES : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1110000-2 |k AG Fluhrer |l Signal Peptide Peptidases as Models for γ-Secretase |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1110000-2 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.2011.07248.x |2 Crossref |o 10.1111/j.1471-4159.2011.07248.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0959-437X(02)00334-9 |2 Crossref |o 10.1016/S0959-437X(02)00334-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/19083 |2 Crossref |o 10.1038/19083 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1096187 |2 Crossref |o 10.1126/science.1096187 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.R800040200 |2 Crossref |o 10.1074/jbc.R800040200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.febslet.2011.08.043 |2 Crossref |o 10.1016/j.febslet.2011.08.043 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncb1440 |2 Crossref |o 10.1038/ncb1440 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1084/jem.20121069 |2 Crossref |o 10.1084/jem.20121069 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1159/000102683 |2 Crossref |o 10.1159/000102683 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1600-0722.1996.tb00053.x |2 Crossref |o 10.1111/j.1600-0722.1996.tb00053.x |
| 999 | C | 5 | |y 1995 |2 Crossref |o Armstrong 1995 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1177/10454411980090020101 |2 Crossref |o 10.1177/10454411980090020101 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ijos.2012.59 |2 Crossref |o 10.1038/ijos.2012.59 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1356-9597.2004.00753.x |2 Crossref |o 10.1111/j.1356-9597.2004.00753.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/74231 |2 Crossref |o 10.1038/74231 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1177/0300985810383870 |2 Crossref |o 10.1177/0300985810383870 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M110.194258 |2 Crossref |o 10.1074/jbc.M110.194258 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1159/000324260 |2 Crossref |o 10.1159/000324260 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1600-0722.2011.00866.x |2 Crossref |o 10.1111/j.1600-0722.2011.00866.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1600-0722.2011.00859.x |2 Crossref |o 10.1111/j.1600-0722.2011.00859.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/jcp.22965 |2 Crossref |o 10.1002/jcp.22965 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1600-0722.2011.00881.x |2 Crossref |o 10.1111/j.1600-0722.2011.00881.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/ajpcell.00218.2010 |2 Crossref |o 10.1152/ajpcell.00218.2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/jbmr.1779 |2 Crossref |o 10.1002/jbmr.1779 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncb1450 |2 Crossref |o 10.1038/ncb1450 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/sj.cdd.4402175 |2 Crossref |o 10.1038/sj.cdd.4402175 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M706661200 |2 Crossref |o 10.1074/jbc.M706661200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1034/j.1600-0714.2001.301004.x |2 Crossref |o 10.1034/j.1600-0714.2001.301004.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1089/omi.2011.0039 |2 Crossref |o 10.1089/omi.2011.0039 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1046/j.0022-7722.2002.00025.x |2 Crossref |o 10.1046/j.0022-7722.2002.00025.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nri3084 |2 Crossref |o 10.1038/nri3084 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1600-0854.2006.00407.x |2 Crossref |o 10.1111/j.1600-0854.2006.00407.x |
| 999 | C | 5 | |y 1999 |2 Crossref |o Miard 1999 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2353/ajpath.2009.080573 |2 Crossref |o 10.2353/ajpath.2009.080573 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.gde.2004.07.008 |2 Crossref |o 10.1016/j.gde.2004.07.008 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|