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@ARTICLE{Popp:136957,
      author       = {Popp, Julius and Meichsner, Sabrina and Kölsch, Heike and
                      Lewczuk, Piotr and Maier, Wolfgang and Kornhuber, Johannes
                      and Jessen, Frank and Lütjohann, Dieter},
      title        = {{C}erebral and extracerebral cholesterol metabolism and
                      {CSF} markers of {A}lzheimer's disease.},
      journal      = {Biochemical pharmacology},
      volume       = {86},
      number       = {1},
      issn         = {0006-2952},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03279},
      pages        = {37-42},
      year         = {2013},
      abstract     = {The disturbances of the cholesterol synthesis and
                      metabolism described in Alzheimer's disease (AD) may be both
                      a consequence of the neurodegenerative process and a
                      contributor to the pathogenesis. These putative
                      relationships and their underlying mechanisms are not well
                      understood. The aim of this study was to evaluate the
                      relationship between the cerebral and extracerebral
                      cholesterol synthesis and metabolism, and the AD pathology
                      as reflected by CSF markers in humans. We evaluated the
                      relationships between the plasma and the cerebrospinal fluid
                      (CSF) concentrations of cholesterol, the cholesterol
                      precursors lanosterol, lathosterol and desmosterol, and the
                      cholesterol elimination products 24S-hydroxycholesterol and
                      27-hydroxycholesterol, and the CSF markers for AD pathology
                      Aβ1-42 and p-tau181 in 86 subjects with normal cognition
                      and in 107 AD patients. CSF desmosterol, cholesterol and
                      24S-hydroxycholesterol in the AD group, and CSF
                      24S-hydroxycholesterol in the control group correlated with
                      the p-tau181 levels. Neither CSF nor plasma concentrations
                      of the included compounds correlated with the CSF Aβ1-42
                      levels. In multivariate regression tests including age,
                      gender, albumin ratio, number of the APOEε4 alleles, and
                      diagnosis, p-tau181 levels independently predicted the CSF
                      desmosterol, cholesterol and 24S-hydroxycholesterol
                      concentrations. The associations remained significant for
                      CSF cholesterol and 24S-hydroxycholesterol when analyses
                      were separately performed in the AD group. The results
                      suggest that alterations of CNS cholesterol de novo genesis
                      and metabolism are related to neurodegeneration and in
                      particular to the cerebral accumulation of phosphorylated
                      tau.},
      keywords     = {Aged / Alzheimer Disease: blood / Alzheimer Disease:
                      cerebrospinal fluid / Alzheimer Disease: metabolism /
                      Amyloid: metabolism / Biomarkers: blood / Biomarkers:
                      cerebrospinal fluid / Brain: metabolism / Case-Control
                      Studies / Cholesterol: metabolism / Female / Humans / Male /
                      tau Proteins: metabolism / Amyloid (NLM Chemicals) /
                      Biomarkers (NLM Chemicals) / tau Proteins (NLM Chemicals) /
                      Cholesterol (NLM Chemicals)},
      cin          = {Pre 2020 / U Clinical Researchers - Bonn / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)999999 / I:(DE-2719)7000001 /
                      I:(DE-2719)1011102},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23291240},
      doi          = {10.1016/j.bcp.2012.12.007},
      url          = {https://pub.dzne.de/record/136957},
}