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000136986 0247_ $$2doi$$a10.1111/jsr.12040
000136986 0247_ $$2pmid$$apmid:23374090
000136986 0247_ $$2ISSN$$a0962-1105
000136986 0247_ $$2ISSN$$a1365-2869
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000136986 037__ $$aDZNE-2020-03308
000136986 041__ $$aEnglish
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000136986 1001_ $$0P:(DE-HGF)0$$aSzentkirályi, András$$b0$$eCorresponding author
000136986 245__ $$aA time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population.
000136986 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2013
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000136986 520__ $$aPrevious cross-sectional studies regarding the association of restless legs syndrome (RLS) with cardiovascular morbidity are controversial. Our aim was to evaluate prospectively the relationship of cardiovascular risk factors and vascular diseases with incident RLS in the general population. The results are from two prospective population-based cohort studies: the Dortmund Health Study (n = 1312, median follow-up of 2.1 years) and the Study of Health in Pomerania (n = 4308, median follow-up of 5.0 years). RLS status was assessed twice according to the minimal criteria. Diabetes, hypertension, myocardial infarction and stroke, as well as currently taken medications, were assessed as self-reports. Body mass index and serum total cholesterol were also measured. The independent risks associated with each outcome were estimated by multivariable logistic regression models adjusted for comorbidities and behavioural factors. Obesity was an independent risk factor of incident RLS in the Dortmund Health Study, and higher body mass index was an independent risk factor in both studies. Diabetes, hypertension and hypercholesterolaemia were independent predictors of incident RLS in the Study of Health in Pomerania. The vascular comorbidity index, defined by the number of concurrent cardiovascular risk factors and vascular diseases, showed a positive association with incident RLS in both studies. RLS at baseline was not a significant predictor of any subsequent cardiovascular risk factors and/or vascular diseases in any of the studies. Cardiovascular risk factors and diseases predict the subsequent development of RLS in the general population. The presence of RLS is not a significant risk factor of cardiovascular morbidity.
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000136986 650_2 $$2MeSH$$aAdult
000136986 650_2 $$2MeSH$$aAged
000136986 650_2 $$2MeSH$$aBody Mass Index
000136986 650_2 $$2MeSH$$aCardiovascular Diseases: epidemiology
000136986 650_2 $$2MeSH$$aCohort Studies
000136986 650_2 $$2MeSH$$aComorbidity
000136986 650_2 $$2MeSH$$aDiabetes Mellitus: epidemiology
000136986 650_2 $$2MeSH$$aFemale
000136986 650_2 $$2MeSH$$aGermany: epidemiology
000136986 650_2 $$2MeSH$$aHumans
000136986 650_2 $$2MeSH$$aHypercholesterolemia: complications
000136986 650_2 $$2MeSH$$aHypercholesterolemia: epidemiology
000136986 650_2 $$2MeSH$$aHypertension: complications
000136986 650_2 $$2MeSH$$aHypertension: epidemiology
000136986 650_2 $$2MeSH$$aIncidence
000136986 650_2 $$2MeSH$$aLogistic Models
000136986 650_2 $$2MeSH$$aMale
000136986 650_2 $$2MeSH$$aMiddle Aged
000136986 650_2 $$2MeSH$$aMyocardial Infarction: complications
000136986 650_2 $$2MeSH$$aMyocardial Infarction: epidemiology
000136986 650_2 $$2MeSH$$aObesity: complications
000136986 650_2 $$2MeSH$$aObesity: epidemiology
000136986 650_2 $$2MeSH$$aProspective Studies
000136986 650_2 $$2MeSH$$aRestless Legs Syndrome: epidemiology
000136986 650_2 $$2MeSH$$aRestless Legs Syndrome: etiology
000136986 650_2 $$2MeSH$$aRisk Factors
000136986 650_2 $$2MeSH$$aStroke: complications
000136986 650_2 $$2MeSH$$aStroke: epidemiology
000136986 650_2 $$2MeSH$$aTime Factors
000136986 650_2 $$2MeSH$$aVascular Diseases: epidemiology
000136986 7001_ $$0P:(DE-HGF)0$$aVölzke, Henry$$b1
000136986 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b2$$udzne
000136986 7001_ $$0P:(DE-HGF)0$$aHappe, Svenja$$b3
000136986 7001_ $$0P:(DE-HGF)0$$aBerger, Klaus$$b4
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000136986 773__ $$0PERI:(DE-600)2007459-1$$a10.1111/jsr.12040$$gVol. 22, no. 4, p. 434 - 442$$n4$$p434-442$$q22:4<434 - 442$$tJournal of sleep research$$v22$$x0962-1105$$y2013
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