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@ARTICLE{Szentkirlyi:136986,
      author       = {Szentkirályi, András and Völzke, Henry and Hoffmann,
                      Wolfgang and Happe, Svenja and Berger, Klaus},
      title        = {{A} time sequence analysis of the relationship between
                      cardiovascular risk factors, vascular diseases and restless
                      legs syndrome in the general population.},
      journal      = {Journal of sleep research},
      volume       = {22},
      number       = {4},
      issn         = {0962-1105},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2020-03308},
      pages        = {434-442},
      year         = {2013},
      abstract     = {Previous cross-sectional studies regarding the association
                      of restless legs syndrome (RLS) with cardiovascular
                      morbidity are controversial. Our aim was to evaluate
                      prospectively the relationship of cardiovascular risk
                      factors and vascular diseases with incident RLS in the
                      general population. The results are from two prospective
                      population-based cohort studies: the Dortmund Health Study
                      (n = 1312, median follow-up of 2.1 years) and the Study
                      of Health in Pomerania (n = 4308, median follow-up of
                      5.0 years). RLS status was assessed twice according to the
                      minimal criteria. Diabetes, hypertension, myocardial
                      infarction and stroke, as well as currently taken
                      medications, were assessed as self-reports. Body mass index
                      and serum total cholesterol were also measured. The
                      independent risks associated with each outcome were
                      estimated by multivariable logistic regression models
                      adjusted for comorbidities and behavioural factors. Obesity
                      was an independent risk factor of incident RLS in the
                      Dortmund Health Study, and higher body mass index was an
                      independent risk factor in both studies. Diabetes,
                      hypertension and hypercholesterolaemia were independent
                      predictors of incident RLS in the Study of Health in
                      Pomerania. The vascular comorbidity index, defined by the
                      number of concurrent cardiovascular risk factors and
                      vascular diseases, showed a positive association with
                      incident RLS in both studies. RLS at baseline was not a
                      significant predictor of any subsequent cardiovascular risk
                      factors and/or vascular diseases in any of the studies.
                      Cardiovascular risk factors and diseases predict the
                      subsequent development of RLS in the general population. The
                      presence of RLS is not a significant risk factor of
                      cardiovascular morbidity.},
      keywords     = {Adult / Aged / Body Mass Index / Cardiovascular Diseases:
                      epidemiology / Cohort Studies / Comorbidity / Diabetes
                      Mellitus: epidemiology / Female / Germany: epidemiology /
                      Humans / Hypercholesterolemia: complications /
                      Hypercholesterolemia: epidemiology / Hypertension:
                      complications / Hypertension: epidemiology / Incidence /
                      Logistic Models / Male / Middle Aged / Myocardial
                      Infarction: complications / Myocardial Infarction:
                      epidemiology / Obesity: complications / Obesity:
                      epidemiology / Prospective Studies / Restless Legs Syndrome:
                      epidemiology / Restless Legs Syndrome: etiology / Risk
                      Factors / Stroke: complications / Stroke: epidemiology /
                      Time Factors / Vascular Diseases: epidemiology},
      cin          = {Translational Health Care Research},
      ddc          = {610},
      cid          = {I:(DE-2719)1510600},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23374090},
      doi          = {10.1111/jsr.12040},
      url          = {https://pub.dzne.de/record/136986},
}