TY  - JOUR
AU  - Hötting, Kirsten
AU  - Holzschneider, Kathrin
AU  - Stenzel, Anna
AU  - Wolbers, Thomas
AU  - Röder, Brigitte
TI  - Effects of a cognitive training on spatial learning and associated functional brain activations.
JO  - BMC neuroscience
VL  - 14
IS  - 1
SN  - 1471-2202
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2020-03325
SP  - 73
PY  - 2013
AB  - Both cognitive and physical exercise have been discussed as promising interventions for healthy cognitive aging. The present study assessed the effects of cognitive training (spatial vs. perceptual training) and physical training (endurance training vs. non-endurance training) on spatial learning and associated brain activation in 33 adults (40-55 years). Spatial learning was assessed with a virtual maze task, and at the same time neural correlates were measured with functional magnetic resonance imaging (fMRI).Only the spatial training improved performance in the maze task. These behavioral gains were accompanied by a decrease in frontal and temporal lobe activity. At posttest, participants of the spatial training group showed lower activity than participants of the perceptual training group in a network of brain regions associated with spatial learning, including the hippocampus and parahippocampal gyrus. No significant differences were observed between the two physical intervention groups.Functional changes in neural systems associated with spatial navigation can be induced by cognitive interventions and seem to be stronger than effects of physical exercise in middle-aged adults.
KW  - Adult
KW  - Brain: blood supply
KW  - Brain: physiology
KW  - Brain Mapping
KW  - Executive Function: physiology
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Maze Learning
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Oxygen: blood
KW  - Oxygen Consumption: physiology
KW  - Physical Endurance
KW  - Physical Fitness: physiology
KW  - Space Perception: physiology
KW  - User-Computer Interface
KW  - Verbal Learning: physiology
KW  - Oxygen (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:23870447
C2  - pmc:PMC3729599
DO  - DOI:10.1186/1471-2202-14-73
UR  - https://pub.dzne.de/record/137003
ER  -