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@ARTICLE{Htting:137003,
      author       = {Hötting, Kirsten and Holzschneider, Kathrin and Stenzel,
                      Anna and Wolbers, Thomas and Röder, Brigitte},
      title        = {{E}ffects of a cognitive training on spatial learning and
                      associated functional brain activations.},
      journal      = {BMC neuroscience},
      volume       = {14},
      number       = {1},
      issn         = {1471-2202},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-03325},
      pages        = {73},
      year         = {2013},
      abstract     = {Both cognitive and physical exercise have been discussed as
                      promising interventions for healthy cognitive aging. The
                      present study assessed the effects of cognitive training
                      (spatial vs. perceptual training) and physical training
                      (endurance training vs. non-endurance training) on spatial
                      learning and associated brain activation in 33 adults (40-55
                      years). Spatial learning was assessed with a virtual maze
                      task, and at the same time neural correlates were measured
                      with functional magnetic resonance imaging (fMRI).Only the
                      spatial training improved performance in the maze task.
                      These behavioral gains were accompanied by a decrease in
                      frontal and temporal lobe activity. At posttest,
                      participants of the spatial training group showed lower
                      activity than participants of the perceptual training group
                      in a network of brain regions associated with spatial
                      learning, including the hippocampus and parahippocampal
                      gyrus. No significant differences were observed between the
                      two physical intervention groups.Functional changes in
                      neural systems associated with spatial navigation can be
                      induced by cognitive interventions and seem to be stronger
                      than effects of physical exercise in middle-aged adults.},
      keywords     = {Adult / Brain: blood supply / Brain: physiology / Brain
                      Mapping / Executive Function: physiology / Female / Humans /
                      Image Processing, Computer-Assisted / Magnetic Resonance
                      Imaging / Male / Maze Learning / Middle Aged /
                      Neuropsychological Tests / Oxygen: blood / Oxygen
                      Consumption: physiology / Physical Endurance / Physical
                      Fitness: physiology / Space Perception: physiology /
                      User-Computer Interface / Verbal Learning: physiology /
                      Oxygen (NLM Chemicals)},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23870447},
      pmc          = {pmc:PMC3729599},
      doi          = {10.1186/1471-2202-14-73},
      url          = {https://pub.dzne.de/record/137003},
}