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000137061 0247_ $$2doi$$a10.1016/j.critrevonc.2013.04.002
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000137061 037__ $$aDZNE-2020-03383
000137061 041__ $$aEnglish
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000137061 1001_ $$aKoppelmans, Vincent$$b0
000137061 245__ $$aLate effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia.
000137061 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2013
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000137061 520__ $$aFew studies have investigated the late (i.e. ≥ 5 years post-treatment) effects of chemotherapy for non-central nervous system (non-CNS) cancer on the brain. Here we discuss the studies that have investigated the late effects of adjuvant chemotherapy for non-CNS cancer on cognitive function (n=6); brain structure and function (n=5); and incidence of dementia (n=4). The neuropsychological studies showed long-term adverse cognitive problems in chemotherapy-exposed breast cancer survivors. This is in line with results from neuroimaging studies that report long-term brain structural alterations after chemotherapy. The studies exploring the association between chemotherapy and the incidence of dementia were contradictive and showed no clear relationship between the two phenomena. Although several methodological issues limit the validity and interpretation of some of the results of these studies, they suggest that chemotherapy is associated with subtle, yet long-lasting cognitive deficits, possibly related to brain structural and functional differences, but as yet not with an increased risk of dementia.
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000137061 650_7 $$2NLM Chemicals$$aAntineoplastic Agents
000137061 650_2 $$2MeSH$$aAge Factors
000137061 650_2 $$2MeSH$$aAntineoplastic Agents: adverse effects
000137061 650_2 $$2MeSH$$aAntineoplastic Agents: therapeutic use
000137061 650_2 $$2MeSH$$aAntineoplastic Combined Chemotherapy Protocols: adverse effects
000137061 650_2 $$2MeSH$$aAntineoplastic Combined Chemotherapy Protocols: therapeutic use
000137061 650_2 $$2MeSH$$aBrain: drug effects
000137061 650_2 $$2MeSH$$aBrain: pathology
000137061 650_2 $$2MeSH$$aChemotherapy, Adjuvant: adverse effects
000137061 650_2 $$2MeSH$$aCognition Disorders: diagnosis
000137061 650_2 $$2MeSH$$aCognition Disorders: etiology
000137061 650_2 $$2MeSH$$aDementia: diagnosis
000137061 650_2 $$2MeSH$$aDementia: etiology
000137061 650_2 $$2MeSH$$aHumans
000137061 650_2 $$2MeSH$$aMental Disorders: diagnosis
000137061 650_2 $$2MeSH$$aMental Disorders: etiology
000137061 650_2 $$2MeSH$$aNeoplasms: complications
000137061 650_2 $$2MeSH$$aNeoplasms: drug therapy
000137061 650_2 $$2MeSH$$aNeuroimaging
000137061 650_2 $$2MeSH$$aNeuropsychological Tests
000137061 650_2 $$2MeSH$$aRisk
000137061 650_2 $$2MeSH$$aSurvivors
000137061 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b1$$udzne
000137061 7001_ $$aBoogerd, Willem$$b2
000137061 7001_ $$aSeynaeve, Caroline$$b3
000137061 7001_ $$0P:(DE-HGF)0$$aSchagen, Sanne B$$b4$$eCorresponding author
000137061 77318 $$2Crossref$$3journal-article$$a10.1016/j.critrevonc.2013.04.002$$b : Elsevier BV, 2013-10-01$$n1$$p87-101$$tCritical Reviews in Oncology/Hematology$$v88$$x1040-8428$$y2013
000137061 773__ $$0PERI:(DE-600)2025731-4$$a10.1016/j.critrevonc.2013.04.002$$gVol. 88, no. 1, p. 87 - 101$$n1$$p87-101$$q88:1<87 - 101$$tCritical reviews in oncology, hematology$$v88$$x1040-8428$$y2013
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