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@ARTICLE{Koppelmans:137061,
      author       = {Koppelmans, Vincent and Breteler, Monique M B and Boogerd,
                      Willem and Seynaeve, Caroline and Schagen, Sanne B},
      title        = {{L}ate effects of adjuvant chemotherapy for adult onset
                      non-{CNS} cancer; cognitive impairment, brain structure and
                      risk of dementia.},
      journal      = {Critical reviews in oncology, hematology},
      volume       = {88},
      number       = {1},
      issn         = {1040-8428},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03383},
      pages        = {87-101},
      year         = {2013},
      abstract     = {Few studies have investigated the late (i.e. ≥ 5 years
                      post-treatment) effects of chemotherapy for non-central
                      nervous system (non-CNS) cancer on the brain. Here we
                      discuss the studies that have investigated the late effects
                      of adjuvant chemotherapy for non-CNS cancer on cognitive
                      function (n=6); brain structure and function (n=5); and
                      incidence of dementia (n=4). The neuropsychological studies
                      showed long-term adverse cognitive problems in
                      chemotherapy-exposed breast cancer survivors. This is in
                      line with results from neuroimaging studies that report
                      long-term brain structural alterations after chemotherapy.
                      The studies exploring the association between chemotherapy
                      and the incidence of dementia were contradictive and showed
                      no clear relationship between the two phenomena. Although
                      several methodological issues limit the validity and
                      interpretation of some of the results of these studies, they
                      suggest that chemotherapy is associated with subtle, yet
                      long-lasting cognitive deficits, possibly related to brain
                      structural and functional differences, but as yet not with
                      an increased risk of dementia.},
      subtyp        = {Review Article},
      keywords     = {Age Factors / Antineoplastic Agents: adverse effects /
                      Antineoplastic Agents: therapeutic use / Antineoplastic
                      Combined Chemotherapy Protocols: adverse effects /
                      Antineoplastic Combined Chemotherapy Protocols: therapeutic
                      use / Brain: drug effects / Brain: pathology / Chemotherapy,
                      Adjuvant: adverse effects / Cognition Disorders: diagnosis /
                      Cognition Disorders: etiology / Dementia: diagnosis /
                      Dementia: etiology / Humans / Mental Disorders: diagnosis /
                      Mental Disorders: etiology / Neoplasms: complications /
                      Neoplasms: drug therapy / Neuroimaging / Neuropsychological
                      Tests / Risk / Survivors / Antineoplastic Agents (NLM
                      Chemicals)},
      cin          = {AG Breteler},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23768778},
      doi          = {10.1016/j.critrevonc.2013.04.002},
      url          = {https://pub.dzne.de/record/137061},
}