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000137086 0247_ $$2doi$$a10.1084/jem.20120201
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000137086 0247_ $$2ISSN$$a0022-1007
000137086 0247_ $$2ISSN$$a1540-9358
000137086 0247_ $$2ISSN$$a1540-9538
000137086 0247_ $$2altmetric$$aaltmetric:1792463
000137086 037__ $$aDZNE-2020-03408
000137086 041__ $$aEnglish
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000137086 1001_ $$0P:(DE-HGF)0$$aSirois, Cherilyn M$$b0
000137086 245__ $$aRAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
000137086 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2013
000137086 264_1 $$2Crossref$$3online$$bRockefeller University Press$$c2013-09-30
000137086 264_1 $$2Crossref$$3print$$bRockefeller University Press$$c2013-10-21
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000137086 520__ $$aRecognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage. Activation of immune signaling receptors by nucleic acids is controlled by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which endosome-resident receptors encounter nucleic acids from the extracellular space are largely undefined. In this study, we show that the receptor for advanced glycation end-products (RAGE) promoted DNA uptake into endosomes and lowered the immune recognition threshold for the activation of Toll-like receptor 9, the principal DNA-recognizing transmembrane signaling receptor. Structural analysis of RAGE-DNA complexes indicated that DNA interacted with dimers of the outermost RAGE extracellular domains, and could induce formation of higher-order receptor complexes. Furthermore, mice deficient in RAGE were unable to mount a typical inflammatory response to DNA in the lung, indicating that RAGE is important for the detection of nucleic acids in vivo.
000137086 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000137086 650_7 $$2NLM Chemicals$$aLigands
000137086 650_7 $$2NLM Chemicals$$aNF-kappa B
000137086 650_7 $$2NLM Chemicals$$aReceptor for Advanced Glycation End Products
000137086 650_7 $$2NLM Chemicals$$aReceptors, Immunologic
000137086 650_7 $$2NLM Chemicals$$aToll-Like Receptor 9
000137086 650_7 $$09007-49-2$$2NLM Chemicals$$aDNA
000137086 650_2 $$2MeSH$$aAnimals
000137086 650_2 $$2MeSH$$aBase Sequence
000137086 650_2 $$2MeSH$$aCell Membrane: metabolism
000137086 650_2 $$2MeSH$$aCrystallography, X-Ray
000137086 650_2 $$2MeSH$$aDNA: chemistry
000137086 650_2 $$2MeSH$$aDNA: metabolism
000137086 650_2 $$2MeSH$$aEndocytosis
000137086 650_2 $$2MeSH$$aEndosomes: metabolism
000137086 650_2 $$2MeSH$$aHEK293 Cells
000137086 650_2 $$2MeSH$$aHeLa Cells
000137086 650_2 $$2MeSH$$aHumans
000137086 650_2 $$2MeSH$$aLigands
000137086 650_2 $$2MeSH$$aLung: metabolism
000137086 650_2 $$2MeSH$$aLung: pathology
000137086 650_2 $$2MeSH$$aMice
000137086 650_2 $$2MeSH$$aMice, Inbred C57BL
000137086 650_2 $$2MeSH$$aModels, Molecular
000137086 650_2 $$2MeSH$$aNF-kappa B: metabolism
000137086 650_2 $$2MeSH$$aPneumonia: metabolism
000137086 650_2 $$2MeSH$$aPneumonia: pathology
000137086 650_2 $$2MeSH$$aProtein Binding
000137086 650_2 $$2MeSH$$aProtein Multimerization
000137086 650_2 $$2MeSH$$aProtein Structure, Tertiary
000137086 650_2 $$2MeSH$$aReceptor for Advanced Glycation End Products
000137086 650_2 $$2MeSH$$aReceptors, Immunologic: chemistry
000137086 650_2 $$2MeSH$$aReceptors, Immunologic: metabolism
000137086 650_2 $$2MeSH$$aStatic Electricity
000137086 650_2 $$2MeSH$$aToll-Like Receptor 9: metabolism
000137086 7001_ $$0P:(DE-HGF)0$$aJin, Tengchuan$$b1
000137086 7001_ $$0P:(DE-HGF)0$$aMiller, Allison L$$b2
000137086 7001_ $$0P:(DE-HGF)0$$aBertheloot, Damien$$b3
000137086 7001_ $$0P:(DE-HGF)0$$aNakamura, Hirotaka$$b4
000137086 7001_ $$0P:(DE-HGF)0$$aHorvath, Gabor L$$b5
000137086 7001_ $$0P:(DE-HGF)0$$aMian, Abubakar$$b6
000137086 7001_ $$0P:(DE-HGF)0$$aJiang, Jiansheng$$b7
000137086 7001_ $$0P:(DE-HGF)0$$aSchrum, Jacob$$b8
000137086 7001_ $$0P:(DE-HGF)0$$aBossaller, Lukas$$b9
000137086 7001_ $$0P:(DE-HGF)0$$aPelka, Karin$$b10
000137086 7001_ $$0P:(DE-HGF)0$$aGarbi, Natalio$$b11
000137086 7001_ $$0P:(DE-HGF)0$$aBrewah, Yambasu$$b12
000137086 7001_ $$0P:(DE-HGF)0$$aTian, Jane$$b13
000137086 7001_ $$0P:(DE-HGF)0$$aChang, ChewShun$$b14
000137086 7001_ $$0P:(DE-HGF)0$$aChowdhury, Partha S$$b15
000137086 7001_ $$0P:(DE-HGF)0$$aSims, Gary P$$b16
000137086 7001_ $$0P:(DE-HGF)0$$aKolbeck, Roland$$b17
000137086 7001_ $$0P:(DE-HGF)0$$aCoyle, Anthony J$$b18
000137086 7001_ $$0P:(DE-HGF)0$$aHumbles, Alison A$$b19
000137086 7001_ $$0P:(DE-HGF)0$$aXiao, T Sam$$b20
000137086 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b21$$eLast author
000137086 77318 $$2Crossref$$3journal-article$$a10.1084/jem.20120201$$b : Rockefeller University Press, 2013-09-30$$n11$$p2447-2463$$tThe Journal of Experimental Medicine$$v210$$x1540-9538$$y2013
000137086 773__ $$0PERI:(DE-600)1477240-1$$a10.1084/jem.20120201$$gVol. 210, no. 11, p. 2447 - 2463$$n11$$p2447-2463$$q210:11<2447 - 2463$$tJournal of experimental medicine$$v210$$x1540-9538$$y2013
000137086 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804942
000137086 909CO $$ooai:pub.dzne.de:137086$$pVDB
000137086 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000062$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b21$$kDZNE
000137086 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000137086 9141_ $$y2013
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