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@ARTICLE{Sirois:137086,
      author       = {Sirois, Cherilyn M and Jin, Tengchuan and Miller, Allison L
                      and Bertheloot, Damien and Nakamura, Hirotaka and Horvath,
                      Gabor L and Mian, Abubakar and Jiang, Jiansheng and Schrum,
                      Jacob and Bossaller, Lukas and Pelka, Karin and Garbi,
                      Natalio and Brewah, Yambasu and Tian, Jane and Chang,
                      ChewShun and Chowdhury, Partha S and Sims, Gary P and
                      Kolbeck, Roland and Coyle, Anthony J and Humbles, Alison A
                      and Xiao, T Sam and Latz, Eicke},
      title        = {{RAGE} is a nucleic acid receptor that promotes
                      inflammatory responses to {DNA}.},
      journal      = {Journal of experimental medicine},
      volume       = {210},
      number       = {11},
      issn         = {1540-9538},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DZNE-2020-03408},
      pages        = {2447-2463},
      year         = {2013},
      abstract     = {Recognition of DNA and RNA molecules derived from pathogens
                      or self-antigen is one way the mammalian immune system
                      senses infection and tissue damage. Activation of immune
                      signaling receptors by nucleic acids is controlled by
                      limiting the access of DNA and RNA to intracellular
                      receptors, but the mechanisms by which endosome-resident
                      receptors encounter nucleic acids from the extracellular
                      space are largely undefined. In this study, we show that the
                      receptor for advanced glycation end-products (RAGE) promoted
                      DNA uptake into endosomes and lowered the immune recognition
                      threshold for the activation of Toll-like receptor 9, the
                      principal DNA-recognizing transmembrane signaling receptor.
                      Structural analysis of RAGE-DNA complexes indicated that DNA
                      interacted with dimers of the outermost RAGE extracellular
                      domains, and could induce formation of higher-order receptor
                      complexes. Furthermore, mice deficient in RAGE were unable
                      to mount a typical inflammatory response to DNA in the lung,
                      indicating that RAGE is important for the detection of
                      nucleic acids in vivo.},
      keywords     = {Animals / Base Sequence / Cell Membrane: metabolism /
                      Crystallography, X-Ray / DNA: chemistry / DNA: metabolism /
                      Endocytosis / Endosomes: metabolism / HEK293 Cells / HeLa
                      Cells / Humans / Ligands / Lung: metabolism / Lung:
                      pathology / Mice / Mice, Inbred C57BL / Models, Molecular /
                      NF-kappa B: metabolism / Pneumonia: metabolism / Pneumonia:
                      pathology / Protein Binding / Protein Multimerization /
                      Protein Structure, Tertiary / Receptor for Advanced
                      Glycation End Products / Receptors, Immunologic: chemistry /
                      Receptors, Immunologic: metabolism / Static Electricity /
                      Toll-Like Receptor 9: metabolism / Ligands (NLM Chemicals) /
                      NF-kappa B (NLM Chemicals) / Receptor for Advanced Glycation
                      End Products (NLM Chemicals) / Receptors, Immunologic (NLM
                      Chemicals) / Toll-Like Receptor 9 (NLM Chemicals) / DNA (NLM
                      Chemicals)},
      cin          = {AG Latz},
      ddc          = {610},
      cid          = {I:(DE-2719)1013024},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24081950},
      pmc          = {pmc:PMC3804942},
      doi          = {10.1084/jem.20120201},
      url          = {https://pub.dzne.de/record/137086},
}