guest ::
| Home > Publications Database > RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. > print |
| Home > Publications Database > RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. > print |
| 001 | 137086 | ||
| 005 | 20240321220203.0 | ||
| 024 | 7 | _ | |a 10.1084/jem.20120201 |2 doi |
| 024 | 7 | _ | |a pmid:24081950 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC3804942 |2 pmc |
| 024 | 7 | _ | |a 0022-1007 |2 ISSN |
| 024 | 7 | _ | |a 1540-9358 |2 ISSN |
| 024 | 7 | _ | |a 1540-9538 |2 ISSN |
| 024 | 7 | _ | |a altmetric:1792463 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-03408 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Sirois, Cherilyn M |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. |
| 260 | _ | _ | |a New York, NY |c 2013 |b Rockefeller Univ. Press |
| 264 | _ | 1 | |3 online |2 Crossref |b Rockefeller University Press |c 2013-09-30 |
| 264 | _ | 1 | |3 print |2 Crossref |b Rockefeller University Press |c 2013-10-21 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1586954685_28576 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage. Activation of immune signaling receptors by nucleic acids is controlled by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which endosome-resident receptors encounter nucleic acids from the extracellular space are largely undefined. In this study, we show that the receptor for advanced glycation end-products (RAGE) promoted DNA uptake into endosomes and lowered the immune recognition threshold for the activation of Toll-like receptor 9, the principal DNA-recognizing transmembrane signaling receptor. Structural analysis of RAGE-DNA complexes indicated that DNA interacted with dimers of the outermost RAGE extracellular domains, and could induce formation of higher-order receptor complexes. Furthermore, mice deficient in RAGE were unable to mount a typical inflammatory response to DNA in the lung, indicating that RAGE is important for the detection of nucleic acids in vivo. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Ligands |2 NLM Chemicals |
| 650 | _ | 7 | |a NF-kappa B |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor for Advanced Glycation End Products |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Immunologic |2 NLM Chemicals |
| 650 | _ | 7 | |a Toll-Like Receptor 9 |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA |0 9007-49-2 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Base Sequence |2 MeSH |
| 650 | _ | 2 | |a Cell Membrane: metabolism |2 MeSH |
| 650 | _ | 2 | |a Crystallography, X-Ray |2 MeSH |
| 650 | _ | 2 | |a DNA: chemistry |2 MeSH |
| 650 | _ | 2 | |a DNA: metabolism |2 MeSH |
| 650 | _ | 2 | |a Endocytosis |2 MeSH |
| 650 | _ | 2 | |a Endosomes: metabolism |2 MeSH |
| 650 | _ | 2 | |a HEK293 Cells |2 MeSH |
| 650 | _ | 2 | |a HeLa Cells |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Ligands |2 MeSH |
| 650 | _ | 2 | |a Lung: metabolism |2 MeSH |
| 650 | _ | 2 | |a Lung: pathology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Models, Molecular |2 MeSH |
| 650 | _ | 2 | |a NF-kappa B: metabolism |2 MeSH |
| 650 | _ | 2 | |a Pneumonia: metabolism |2 MeSH |
| 650 | _ | 2 | |a Pneumonia: pathology |2 MeSH |
| 650 | _ | 2 | |a Protein Binding |2 MeSH |
| 650 | _ | 2 | |a Protein Multimerization |2 MeSH |
| 650 | _ | 2 | |a Protein Structure, Tertiary |2 MeSH |
| 650 | _ | 2 | |a Receptor for Advanced Glycation End Products |2 MeSH |
| 650 | _ | 2 | |a Receptors, Immunologic: chemistry |2 MeSH |
| 650 | _ | 2 | |a Receptors, Immunologic: metabolism |2 MeSH |
| 650 | _ | 2 | |a Static Electricity |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptor 9: metabolism |2 MeSH |
| 700 | 1 | _ | |a Jin, Tengchuan |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Miller, Allison L |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Bertheloot, Damien |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Nakamura, Hirotaka |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Horvath, Gabor L |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Mian, Abubakar |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Jiang, Jiansheng |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Schrum, Jacob |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Bossaller, Lukas |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Pelka, Karin |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Garbi, Natalio |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Brewah, Yambasu |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Tian, Jane |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Chang, ChewShun |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Chowdhury, Partha S |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Sims, Gary P |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Kolbeck, Roland |0 P:(DE-HGF)0 |b 17 |
| 700 | 1 | _ | |a Coyle, Anthony J |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Humbles, Alison A |0 P:(DE-HGF)0 |b 19 |
| 700 | 1 | _ | |a Xiao, T Sam |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Latz, Eicke |0 P:(DE-2719)2000062 |b 21 |e Last author |
| 773 | 1 | 8 | |a 10.1084/jem.20120201 |b : Rockefeller University Press, 2013-09-30 |n 11 |p 2447-2463 |3 journal-article |2 Crossref |t The Journal of Experimental Medicine |v 210 |y 2013 |x 1540-9538 |
| 773 | _ | _ | |a 10.1084/jem.20120201 |g Vol. 210, no. 11, p. 2447 - 2463 |0 PERI:(DE-600)1477240-1 |n 11 |q 210:11<2447 - 2463 |p 2447-2463 |t Journal of experimental medicine |v 210 |y 2013 |x 1540-9538 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804942 |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:137086 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 21 |6 P:(DE-2719)2000062 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |2 G:(DE-HGF)POF3-300 |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2013 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J EXP MED : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b J EXP MED : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1013024 |k AG Latz |l Innate Immunity in Neurodegeneration |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013024 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |a 10.1107/S0907444909052925 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444909052925 |
| 999 | C | 5 | |a 10.1002/pros.20736 |9 -- missing cx lookup -- |2 Crossref |o 10.1002/pros.20736 |
| 999 | C | 5 | |a 10.1189/jlb.0510262 |9 -- missing cx lookup -- |2 Crossref |o 10.1189/jlb.0510262 |
| 999 | C | 5 | |a 10.1038/ni1280 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/ni1280 |
| 999 | C | 5 | |a 10.2337/diabetes.50.12.2792 |9 -- missing cx lookup -- |2 Crossref |o 10.2337/diabetes.50.12.2792 |
| 999 | C | 5 | |a 10.1073/pnas.1014051107 |9 -- missing cx lookup -- |2 Crossref |o 10.1073/pnas.1014051107 |
| 999 | C | 5 | |y 1993 |2 Crossref |o Brett 1993 |
| 999 | C | 5 | |a 10.1155/2010/917108 |9 -- missing cx lookup -- |2 Crossref |o 10.1155/2010/917108 |
| 999 | C | 5 | |a 10.1107/S0907444909042073 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444909042073 |
| 999 | C | 5 | |y 2000 |2 Crossref |o Chuang 2000 |
| 999 | C | 5 | |a 10.1093/hmg/ddp293 |9 -- missing cx lookup -- |2 Crossref |o 10.1093/hmg/ddp293 |
| 999 | C | 5 | |a 10.1093/nar/gkg316 |9 -- missing cx lookup -- |2 Crossref |o 10.1093/nar/gkg316 |
| 999 | C | 5 | |a 10.1021/bi7003735 |9 -- missing cx lookup -- |2 Crossref |o 10.1021/bi7003735 |
| 999 | C | 5 | |a 10.1007/s00441-005-0069-0 |9 -- missing cx lookup -- |2 Crossref |o 10.1007/s00441-005-0069-0 |
| 999 | C | 5 | |a 10.1189/jlb.0306171 |9 -- missing cx lookup -- |2 Crossref |o 10.1189/jlb.0306171 |
| 999 | C | 5 | |a 10.1107/S0907444904019158 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444904019158 |
| 999 | C | 5 | |a 10.1016/j.gene.2003.08.022 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.gene.2003.08.022 |
| 999 | C | 5 | |a 10.1038/nature07405 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nature07405 |
| 999 | C | 5 | |a 10.1084/jem.20100682 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.20100682 |
| 999 | C | 5 | |a 10.1084/jem.20101102 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.20101102 |
| 999 | C | 5 | |a 10.1016/j.immuni.2008.01.013 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2008.01.013 |
| 999 | C | 5 | |a 10.4049/jimmunol.164.3.1617 |9 -- missing cx lookup -- |2 Crossref |o 10.4049/jimmunol.164.3.1617 |
| 999 | C | 5 | |a 10.1038/35047123 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/35047123 |
| 999 | C | 5 | |a 10.1016/S0092-8674(00)80801-6 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/S0092-8674(00)80801-6 |
| 999 | C | 5 | |a 10.1038/nature03547 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nature03547 |
| 999 | C | 5 | |a 10.1126/science.7761829 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/science.7761829 |
| 999 | C | 5 | |a 10.1038/nri2690 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nri2690 |
| 999 | C | 5 | |a 10.1038/ni.1631 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/ni.1631 |
| 999 | C | 5 | |a 10.1155/2010/498980 |9 -- missing cx lookup -- |2 Crossref |o 10.1155/2010/498980 |
| 999 | C | 5 | |a 10.1074/jbc.M801465200 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.M801465200 |
| 999 | C | 5 | |a 10.1074/jbc.274.28.19919 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.274.28.19919 |
| 999 | C | 5 | |a 10.1107/S0907444909047337 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444909047337 |
| 999 | C | 5 | |a 10.1096/fj.08-117739 |9 -- missing cx lookup -- |2 Crossref |o 10.1096/fj.08-117739 |
| 999 | C | 5 | |a 10.1073/pnas.1010603107 |9 -- missing cx lookup -- |2 Crossref |o 10.1073/pnas.1010603107 |
| 999 | C | 5 | |a 10.1016/j.str.2010.05.017 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.str.2010.05.017 |
| 999 | C | 5 | |a 10.1038/ni0507-475 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/ni0507-475 |
| 999 | C | 5 | |a 10.1016/0005-2787(70)90489-2 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/0005-2787(70)90489-2 |
| 999 | C | 5 | |a 10.1074/jbc.272.28.17810 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.272.28.17810 |
| 999 | C | 5 | |a 10.1038/nature07115 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nature07115 |
| 999 | C | 5 | |a 10.1074/jbc.272.26.16498 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.272.26.16498 |
| 999 | C | 5 | |a 10.1107/S0021889807021206 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0021889807021206 |
| 999 | C | 5 | |a 10.1093/infdis/jir826 |9 -- missing cx lookup -- |2 Crossref |o 10.1093/infdis/jir826 |
| 999 | C | 5 | |a 10.4049/jimmunol.179.12.8051 |9 -- missing cx lookup -- |2 Crossref |o 10.4049/jimmunol.179.12.8051 |
| 999 | C | 5 | |a 10.1038/76032 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/76032 |
| 999 | C | 5 | |a 10.1038/sj.emboj.7601805 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/sj.emboj.7601805 |
| 999 | C | 5 | |a 10.1016/S0076-6879(97)76066-X |9 -- missing cx lookup -- |2 Crossref |o 10.1016/S0076-6879(97)76066-X |
| 999 | C | 5 | |a 10.1107/S0907444906005270 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444906005270 |
| 999 | C | 5 | |a 10.1074/jbc.M110.169276 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.M110.169276 |
| 999 | C | 5 | |a 10.1038/ni.1669 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/ni.1669 |
| 999 | C | 5 | |a 10.1107/S0907444903008126 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444903008126 |
| 999 | C | 5 | |a 10.1189/jlb.0409230 |9 -- missing cx lookup -- |2 Crossref |o 10.1189/jlb.0409230 |
| 999 | C | 5 | |a 10.1016/j.molmed.2009.06.003 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.molmed.2009.06.003 |
| 999 | C | 5 | |a 10.4049/jimmunol.1000863 |9 -- missing cx lookup -- |2 Crossref |o 10.4049/jimmunol.1000863 |
| 999 | C | 5 | |a 10.1074/jbc.M111.223438 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.M111.223438 |
| 999 | C | 5 | |a 10.1126/science.1187029 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/science.1187029 |
| 999 | C | 5 | |a 10.1016/j.immuni.2009.05.008 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2009.05.008 |
| 999 | C | 5 | |a 10.1146/annurev.immunol.021908.132603 |9 -- missing cx lookup -- |2 Crossref |o 10.1146/annurev.immunol.021908.132603 |
| 999 | C | 5 | |a 10.1002/jcb.22575 |9 -- missing cx lookup -- |2 Crossref |o 10.1002/jcb.22575 |
| 999 | C | 5 | |a 10.1016/j.cmpb.2004.02.004 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.cmpb.2004.02.004 |
| 999 | C | 5 | |a 10.1146/annurev.immunol.21.120601.141126 |9 -- missing cx lookup -- |2 Crossref |o 10.1146/annurev.immunol.21.120601.141126 |
| 999 | C | 5 | |a 10.1038/ni1457 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/ni1457 |
| 999 | C | 5 | |a 10.1002/eji.200324032 |9 -- missing cx lookup -- |2 Crossref |o 10.1002/eji.200324032 |
| 999 | C | 5 | |a 10.1021/cb4001553 |9 -- missing cx lookup -- |2 Crossref |o 10.1021/cb4001553 |
| 999 | C | 5 | |y 1994 |2 Crossref |o Yan 1994 |
| 999 | C | 5 | |a 10.1080/07853890902806576 |9 -- missing cx lookup -- |2 Crossref |o 10.1080/07853890902806576 |
| 999 | C | 5 | |a 10.1038/nature08512 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nature08512 |
| 999 | C | 5 | |a 10.1107/S0907444904019419 |9 -- missing cx lookup -- |2 Crossref |o 10.1107/S0907444904019419 |
| 999 | C | 5 | |a 10.1074/jbc.M110.133827 |9 -- missing cx lookup -- |2 Crossref |o 10.1074/jbc.M110.133827 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|