TY  - JOUR
AU  - Acosta-Cabronero, Julio
AU  - Williams, Guy B
AU  - Cardenas-Blanco, Arturo
AU  - Arnold, Robert J
AU  - Lupson, Victoria
AU  - Nestor, Peter J
TI  - In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease.
JO  - PLOS ONE
VL  - 8
IS  - 11
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DZNE-2020-03465
SP  - e81093
PY  - 2013
AB  - This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies.In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations.The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei-particularly the putamen-as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies.
KW  - Adult
KW  - Aged
KW  - Alzheimer Disease: diagnosis
KW  - Brain: pathology
KW  - Brain Mapping
KW  - Case-Control Studies
KW  - Female
KW  - Humans
KW  - Image Interpretation, Computer-Assisted: methods
KW  - Image Processing, Computer-Assisted: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Reproducibility of Results
LB  - PUB:(DE-HGF)16
C6  - pmid:24278382
C2  - pmc:PMC3836742
DO  - DOI:10.1371/journal.pone.0081093
UR  - https://pub.dzne.de/record/137143
ER  -