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@ARTICLE{AcostaCabronero:137143,
      author       = {Acosta-Cabronero, Julio and Williams, Guy B and
                      Cardenas-Blanco, Arturo and Arnold, Robert J and Lupson,
                      Victoria and Nestor, Peter J},
      title        = {{I}n vivo quantitative susceptibility mapping ({QSM}) in
                      {A}lzheimer's disease.},
      journal      = {PLOS ONE},
      volume       = {8},
      number       = {11},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2020-03465},
      pages        = {e81093},
      year         = {2013},
      abstract     = {This study explores the magnetostatic properties of the
                      Alzheimer's disease brain using a recently proposed,
                      magnetic resonance imaging, postprocessed contrast
                      mechanism. Quantitative susceptibility mapping (QSM) has the
                      potential to monitor in vivo iron levels by reconstructing
                      magnetic susceptibility sources from field perturbations.
                      However, with phase data acquired at a single head
                      orientation, the technique relies on several theoretical
                      approximations and requires fast-evolving regularisation
                      strategies.In this context, the present study describes a
                      complete methodological framework for magnetic
                      susceptibility measurements with a review of its theoretical
                      foundations.The regional and whole-brain cross-sectional
                      comparisons between Alzheimer's disease subjects and matched
                      controls indicate that there may be significant magnetic
                      susceptibility differences for deep brain
                      nuclei--particularly the putamen--as well as for posterior
                      grey and white matter regions. The methodology and findings
                      described suggest that the QSM method is ready for
                      larger-scale clinical studies.},
      keywords     = {Adult / Aged / Alzheimer Disease: diagnosis / Brain:
                      pathology / Brain Mapping / Case-Control Studies / Female /
                      Humans / Image Interpretation, Computer-Assisted: methods /
                      Image Processing, Computer-Assisted: methods / Magnetic
                      Resonance Imaging: methods / Male / Reproducibility of
                      Results},
      cin          = {AG Nestor / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)1310001 / I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24278382},
      pmc          = {pmc:PMC3836742},
      doi          = {10.1371/journal.pone.0081093},
      url          = {https://pub.dzne.de/record/137143},
}