Home > Publications Database > Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. > print

001     137195
005     20240321220216.0
024 7 _ |a 10.1371/journal.pone.0083714
|2 doi
024 7 _ |a pmid:24386261
|2 pmid
024 7 _ |a pmc:PMC3875477
|2 pmc
024 7 _ |a altmetric:2013527
|2 altmetric
037 _ _ |a DZNE-2020-03517
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Zhu, Jun-Yi
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.
260 _ _ |a San Francisco, California, US
|c 2013
|b PLOS
264 _ 1 |3 online
|2 Crossref
|b Public Library of Science (PLoS)
|c 2013-12-30
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1602761126_13710
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. Mortalin dysfunction associated with Parkinson's disease (PD) increases the vulnerability of cultured cells to proteolytic stress and leads to changes in mitochondrial function and morphology. To date, Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes. We generated the first loss-of-Hsc70-5/mortalin-function Drosophila model. The reduction of Mortalin expression recapitulates some of the defects observed in the existing Drosophila PD-models, which include reduced ATP levels, abnormal wing posture, shortened life span, and reduced spontaneous locomotor and climbing ability. Dopaminergic neurons seem to be more sensitive to the loss of mortalin than other neuronal sub-types and non-neuronal tissues. The loss of synaptic mitochondria is an early pathological change that might cause later degenerative events. It precedes both behavioral abnormalities and structural changes at the neuromuscular junction (NMJ) of mortalin-knockdown larvae that exhibit increased mitochondrial fragmentation. Autophagy is concomitantly up-regulated, suggesting that mitochondria are degraded via mitophagy. Ex vivo data from human fibroblasts identifies increased mitophagy as an early pathological change that precedes apoptosis. Given the specificity of the observed defects, we are confident that the loss-of-mortalin model presented in this study will be useful for further dissection of the complex network of pathways that underlie the development of mitochondrial parkinsonism.
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
|0 G:(DE-HGF)POF3-345
|c POF3-345
|f POF III
|x 0
542 _ _ |i 2013-12-30
|2 Crossref
|u http://creativecommons.org/licenses/by/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a HSP70 Heat-Shock Proteins
|2 NLM Chemicals
650 _ 7 |a mortalin
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Autophagy: genetics
|2 MeSH
650 _ 2 |a Cell Survival: genetics
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Dopaminergic Neurons: metabolism
|2 MeSH
650 _ 2 |a Drosophila
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Gene Knockdown Techniques
|2 MeSH
650 _ 2 |a Gene Silencing
|2 MeSH
650 _ 2 |a Genes, Essential
|2 MeSH
650 _ 2 |a HSP70 Heat-Shock Proteins: genetics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mitochondria: genetics
|2 MeSH
650 _ 2 |a Mitochondria: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Parkinson Disease: genetics
|2 MeSH
650 _ 2 |a Parkinson Disease: metabolism
|2 MeSH
650 _ 2 |a Phenotype
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
700 1 _ |a Vereshchagina, Natalia
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Sreekumar, Vrinda
|0 P:(DE-2719)2801323
|b 2
|u dzne
700 1 _ |a Burbulla, Lena F
|0 P:(DE-2719)9000040
|b 3
|u dzne
700 1 _ |a Costa, Ana C
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Daub, Katharina J
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Woitalla, Dirk
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Martins, L Miguel
|0 P:(DE-HGF)0
|b 7
700 1 _ |a Krüger, Rejko
|0 P:(DE-2719)2811170
|b 8
|u dzne
700 1 _ |a Rasse, Tobias M
|0 P:(DE-HGF)0
|b 9
773 1 8 |a 10.1371/journal.pone.0083714
|b : Public Library of Science (PLoS), 2013-12-30
|n 12
|p e83714
|3 journal-article
|2 Crossref
|t PLoS ONE
|v 8
|y 2013
|x 1932-6203
773 _ _ |a 10.1371/journal.pone.0083714
|g Vol. 8, no. 12, p. e83714 -
|0 PERI:(DE-600)2267670-3
|n 12
|q 8:12|p e83714
|t PLOS ONE
|v 8
|y 2013
|x 1932-6203
856 4 _ |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083714
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875477
856 4 _ |u https://pub.dzne.de/record/137195/files/895.PDF
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/137195/files/895.gif?subformat=icon
|x icon
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/137195/files/895.jpg?subformat=icon-1440
|x icon-1440
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/137195/files/895.jpg?subformat=icon-180
|x icon-180
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/137195/files/895.jpg?subformat=icon-640
|x icon-640
|y OpenAccess
909 C O |o oai:pub.dzne.de:137195
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2801323
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)9000040
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 8
|6 P:(DE-2719)2811170
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-345
|2 G:(DE-HGF)POF3-300
|v Population Studies and Genetics
|x 0
914 1 _ |y 2013
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b PLOS ONE : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 1 _ |0 I:(DE-2719)1210000
|k AG Gasser 1
|l Parkinson Genetics
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1210000
980 1 _ |a FullTexts
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0896-6273(03)00568-3
|2 Crossref
|o 10.1016/S0896-6273(03)00568-3
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrg1831
|2 Crossref
|o 10.1038/nrg1831
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrneurol.2012.126
|2 Crossref
|o 10.1038/nrneurol.2012.126
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s12031-010-9488-9
|2 Crossref
|o 10.1007/s12031-010-9488-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/B978-0-12-385883-2.00011-4
|2 Crossref
|o 10.1016/B978-0-12-385883-2.00011-4
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1365-2362.2010.02354.x
|2 Crossref
|o 10.1111/j.1365-2362.2010.02354.x
999 C 5 |9 -- missing cx lookup --
|a 10.2174/092986609788167770
|2 Crossref
|o 10.2174/092986609788167770
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s10522-008-9174-2
|2 Crossref
|o 10.1007/s10522-008-9174-2
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.84.12.4156
|2 Crossref
|o 10.1073/pnas.84.12.4156
999 C 5 |9 -- missing cx lookup --
|a 10.1002/jgm.530
|2 Crossref
|o 10.1002/jgm.530
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0014-5793(02)02470-5
|2 Crossref
|o 10.1016/S0014-5793(02)02470-5
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0014-4827(03)00101-0
|2 Crossref
|o 10.1016/S0014-4827(03)00101-0
999 C 5 |9 -- missing cx lookup --
|a 10.1097/nen.0b013e318163354a
|2 Crossref
|o 10.1097/nen.0b013e318163354a
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.23647
|2 Crossref
|o 10.1002/mds.23647
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00702-009-0273-2
|2 Crossref
|o 10.1007/s00702-009-0273-2
999 C 5 |9 -- missing cx lookup --
|a 10.1093/hmg/ddq370
|2 Crossref
|o 10.1093/hmg/ddq370
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.bbrc.2011.05.116
|2 Crossref
|o 10.1016/j.bbrc.2011.05.116
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.cub.2005.07.036
|2 Crossref
|o 10.1016/j.cub.2005.07.036
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.gene.2005.06.040
|2 Crossref
|o 10.1016/j.gene.2005.06.040
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature04779
|2 Crossref
|o 10.1038/nature04779
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature04788
|2 Crossref
|o 10.1038/nature04788
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0709336105
|2 Crossref
|o 10.1073/pnas.0709336105
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0737556100
|2 Crossref
|o 10.1073/pnas.0737556100
999 C 5 |9 -- missing cx lookup --
|a 10.1038/cdd.2012.5
|2 Crossref
|o 10.1038/cdd.2012.5
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature05954
|2 Crossref
|o 10.1038/nature05954
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn1484
|2 Crossref
|o 10.1038/nn1484
999 C 5 |9 -- missing cx lookup --
|a 10.1007/978-1-59745-583-1_14
|2 Crossref
|o 10.1007/978-1-59745-583-1_14
999 C 5 |9 -- missing cx lookup --
|a 10.1534/genetics.113.151639
|2 Crossref
|o 10.1534/genetics.113.151639
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nprot.2007.472
|2 Crossref
|o 10.1038/nprot.2007.472
999 C 5 |9 -- missing cx lookup --
|a 10.4161/auto.5.7.9325
|2 Crossref
|o 10.4161/auto.5.7.9325
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pone.0017808
|2 Crossref
|o 10.1371/journal.pone.0017808
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pgen.1003066
|2 Crossref
|o 10.1371/journal.pgen.1003066
999 C 5 |9 -- missing cx lookup --
|a 10.1093/hmg/dds526
|2 Crossref
|o 10.1093/hmg/dds526
999 C 5 |9 -- missing cx lookup --
|a 10.1196/annals.1395.032
|2 Crossref
|o 10.1196/annals.1395.032
999 C 5 |9 -- missing cx lookup --
|a 10.1097/00019052-199608000-00007
|2 Crossref
|o 10.1097/00019052-199608000-00007
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pone.0039054
|2 Crossref
|o 10.1371/journal.pone.0039054
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature08799
|2 Crossref
|o 10.1038/nature08799
999 C 5 |9 -- missing cx lookup --
|a 10.1101/gr.6940108
|2 Crossref
|o 10.1101/gr.6940108
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0602493103
|2 Crossref
|o 10.1073/pnas.0602493103
999 C 5 |9 -- missing cx lookup --
|a 10.1093/hmg/ddr609
|2 Crossref
|o 10.1093/hmg/ddr609
999 C 5 |9 -- missing cx lookup --
|a 10.4161/auto.19496
|2 Crossref
|o 10.4161/auto.19496
999 C 5 |y 2011
|2 Crossref
|o A Rakovic 2011
999 C 5 |9 -- missing cx lookup --
|a 10.1074/mcp.M600182-MCP200
|2 Crossref
|o 10.1074/mcp.M600182-MCP200
999 C 5 |9 -- missing cx lookup --
|a 10.1002/pmic.200900126
|2 Crossref
|o 10.1002/pmic.200900126
999 C 5 |9 -- missing cx lookup --
|a 10.1038/371768a0
|2 Crossref
|o 10.1038/371768a0
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awg170
|2 Crossref
|o 10.1093/brain/awg170
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature11707
|2 Crossref
|o 10.1038/nature11707
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.3704638
|2 Crossref
|o 10.1126/science.3704638
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.cell.2008.06.016
|2 Crossref
|o 10.1016/j.cell.2008.06.016
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1749-6632.1992.tb24527.x
|2 Crossref
|o 10.1111/j.1749-6632.1992.tb24527.x
999 C 5 |y 1998
|2 Crossref
|o A Sadun 1998
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awp158
|2 Crossref
|o 10.1093/brain/awp158
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.1120688109
|2 Crossref
|o 10.1073/pnas.1120688109
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1471-4914(03)00020-0
|2 Crossref
|o 10.1016/S1471-4914(03)00020-0
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.25135
|2 Crossref
|o 10.1002/mds.25135

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21