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000137231 0247_ $$2doi$$a10.1097/PSY.0b013e31828bbbf1
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000137231 0247_ $$2ISSN$$a0033-3174
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000137231 037__ $$aDZNE-2020-03553
000137231 041__ $$aEnglish
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000137231 1001_ $$0P:(DE-HGF)0$$aSzentkiralyi, Andras$$b0$$eCorresponding author
000137231 245__ $$aThe relationship between depressive symptoms and restless legs syndrome in two prospective cohort studies.
000137231 260__ $$aPhiladelphia, Pa.$$bLippincott Williams & Wilkins$$c2013
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000137231 520__ $$aCross-sectional studies suggest a strong association between depression and restless legs syndrome (RLS); however, the temporal relationship between the two disorders remains unknown. We tested whether the presence of clinically relevant depressive symptoms (CRDS) is a risk factor for subsequent RLS in the general population. The relationship between prevalent RLS and incident CRDS was also examined.Two independent, prospective cohort studies with representative, age-stratified random samples, the Dortmund Health Study (DHS; n = 1312/1122 [baseline/follow-up], median follow-up time = 2.1 years) and the Study of Health in Pomerania (SHIP; n = 4308/3300, median follow-up time = 5.0 years) were analyzed. RLS was assessed in both studies according to the RLS minimal criteria, at baseline and at follow-up. CRDS were assessed by the Center for Epidemiologic Studies-Depression scale (a score of ≥16) in DHS only at baseline and by the Munich-Composite International Diagnostic-Screener in SHIP at baseline and at follow-up.Clinically relevant depressive symptoms at baseline were associated new-onset RLS in both studies (DHS: odds ratio [OR] = 1.94, 95% confidence interval [CI] = 1.09-3.44; SHIP: OR = 2.37, 95% CI = 1.65-3.40) after adjustment for age, sex, education, body mass index, smoking, physical activity, and the presence of various comorbidities. RLS at baseline was an independent risk factor of incident CRDS in SHIP (OR = 1.82, 95% CI = 1.10-3.00).The presence of CRDS may be a risk factor for subsequent RLS. The relationship between the two disorders might be bidirectional because RLS also predicts incident depressive symptoms.
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000137231 650_2 $$2MeSH$$aAdult
000137231 650_2 $$2MeSH$$aAged
000137231 650_2 $$2MeSH$$aComorbidity
000137231 650_2 $$2MeSH$$aDepression: epidemiology
000137231 650_2 $$2MeSH$$aFemale
000137231 650_2 $$2MeSH$$aFollow-Up Studies
000137231 650_2 $$2MeSH$$aGermany: epidemiology
000137231 650_2 $$2MeSH$$aHealth Surveys
000137231 650_2 $$2MeSH$$aHumans
000137231 650_2 $$2MeSH$$aIncidence
000137231 650_2 $$2MeSH$$aMale
000137231 650_2 $$2MeSH$$aMiddle Aged
000137231 650_2 $$2MeSH$$aMotor Activity
000137231 650_2 $$2MeSH$$aObesity: epidemiology
000137231 650_2 $$2MeSH$$aPrevalence
000137231 650_2 $$2MeSH$$aProspective Studies
000137231 650_2 $$2MeSH$$aRestless Legs Syndrome: epidemiology
000137231 650_2 $$2MeSH$$aRestless Legs Syndrome: psychology
000137231 650_2 $$2MeSH$$aRisk Factors
000137231 650_2 $$2MeSH$$aSampling Studies
000137231 650_2 $$2MeSH$$aSmoking: epidemiology
000137231 650_2 $$2MeSH$$aSurveys and Questionnaires
000137231 650_2 $$2MeSH$$aYoung Adult
000137231 7001_ $$0P:(DE-HGF)0$$aVölzke, Henry$$b1
000137231 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b2$$udzne
000137231 7001_ $$0P:(DE-HGF)0$$aBaune, Bernhard T$$b3
000137231 7001_ $$0P:(DE-HGF)0$$aBerger, Klaus$$b4
000137231 77318 $$2Crossref$$3journal-article$$a10.1097/psy.0b013e31828bbbf1$$b : Ovid Technologies (Wolters Kluwer Health), 2013-05-01$$n4$$p359-365$$tPsychosomatic Medicine$$v75$$x0033-3174$$y2013
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