TY  - JOUR
AU  - Szentkiralyi, Andras
AU  - Völzke, Henry
AU  - Hoffmann, Wolfgang
AU  - Baune, Bernhard T
AU  - Berger, Klaus
TI  - The relationship between depressive symptoms and restless legs syndrome in two prospective cohort studies.
JO  - Psychosomatic medicine
VL  - 75
IS  - 4
SN  - 0033-3174
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DZNE-2020-03553
SP  - 359-365
PY  - 2013
AB  - Cross-sectional studies suggest a strong association between depression and restless legs syndrome (RLS); however, the temporal relationship between the two disorders remains unknown. We tested whether the presence of clinically relevant depressive symptoms (CRDS) is a risk factor for subsequent RLS in the general population. The relationship between prevalent RLS and incident CRDS was also examined.Two independent, prospective cohort studies with representative, age-stratified random samples, the Dortmund Health Study (DHS; n = 1312/1122 [baseline/follow-up], median follow-up time = 2.1 years) and the Study of Health in Pomerania (SHIP; n = 4308/3300, median follow-up time = 5.0 years) were analyzed. RLS was assessed in both studies according to the RLS minimal criteria, at baseline and at follow-up. CRDS were assessed by the Center for Epidemiologic Studies-Depression scale (a score of ≥16) in DHS only at baseline and by the Munich-Composite International Diagnostic-Screener in SHIP at baseline and at follow-up.Clinically relevant depressive symptoms at baseline were associated new-onset RLS in both studies (DHS: odds ratio [OR] = 1.94, 95
KW  - Adult
KW  - Aged
KW  - Comorbidity
KW  - Depression: epidemiology
KW  - Female
KW  - Follow-Up Studies
KW  - Germany: epidemiology
KW  - Health Surveys
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Motor Activity
KW  - Obesity: epidemiology
KW  - Prevalence
KW  - Prospective Studies
KW  - Restless Legs Syndrome: epidemiology
KW  - Restless Legs Syndrome: psychology
KW  - Risk Factors
KW  - Sampling Studies
KW  - Smoking: epidemiology
KW  - Surveys and Questionnaires
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:23576767
DO  - DOI:10.1097/PSY.0b013e31828bbbf1
UR  - https://pub.dzne.de/record/137231
ER  -