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@ARTICLE{Krhling:137234,
      author       = {Krähling, Anke Miriam and Alvarez, Luis and Debowski,
                      Katharina and Van, Qui and Gunkel, Monika and Irsen, Stephan
                      and Alamoudi, Ashraf and Strünker, Timo and Kremmer,
                      Elisabeth and Krause, Eberhard and Voigt, Ingo and Wörtge,
                      Simone and Waisman, Ari and Weyand, Ingo and Seifert,
                      Reinhard and Kaupp, Ulrich Benjamin and Wachten, Dagmar},
      title        = {{CRIS}-a novel c{AMP}-binding protein controlling
                      spermiogenesis and the development of flagellar bending.},
      journal      = {PLoS Genetics},
      volume       = {9},
      number       = {12},
      issn         = {1553-7404},
      address      = {San Francisco, Calif.},
      publisher    = {Public Library of Science},
      reportid     = {DZNE-2020-03556},
      pages        = {e1003960},
      year         = {2013},
      abstract     = {The second messengers cAMP and cGMP activate their target
                      proteins by binding to a conserved cyclic nucleotide-binding
                      domain (CNBD). Here, we identify and characterize an
                      entirely novel CNBD-containing protein called CRIS (cyclic
                      nucleotide receptor involved in sperm function) that is
                      unrelated to any of the other members of this protein
                      family. CRIS is exclusively expressed in sperm precursor
                      cells. Cris-deficient male mice are either infertile due to
                      a lack of sperm resulting from spermatogenic arrest, or
                      subfertile due to impaired sperm motility. The motility
                      defect is caused by altered Ca(2+) regulation of flagellar
                      beat asymmetry, leading to a beating pattern that is
                      reminiscent of sperm hyperactivation. Our results suggest
                      that CRIS interacts during spermiogenesis with
                      Ca(2+)-regulated proteins that--in mature sperm--are
                      involved in flagellar bending.},
      keywords     = {Animals / Calcium: metabolism / Carrier Proteins: genetics
                      / Cyclic AMP: genetics / Cyclic AMP: metabolism / Cyclic
                      GMP: metabolism / Flagella: genetics / Flagella: metabolism
                      / Humans / Intracellular Signaling Peptides and Proteins /
                      Male / Mice / Phosphorylation / Protein Binding: genetics /
                      Signal Transduction: genetics / Sperm Motility: genetics /
                      Spermatogenesis: genetics / Spermatozoa: metabolism / CRIS
                      protein, mouse (NLM Chemicals) / Carrier Proteins (NLM
                      Chemicals) / Intracellular Signaling Peptides and Proteins
                      (NLM Chemicals) / Cyclic AMP (NLM Chemicals) / Cyclic GMP
                      (NLM Chemicals) / Calcium (NLM Chemicals)},
      cin          = {AG Alamoudi},
      ddc          = {610},
      cid          = {I:(DE-2719)1013012},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24339785},
      pmc          = {pmc:PMC3854790},
      doi          = {10.1371/journal.pgen.1003960},
      url          = {https://pub.dzne.de/record/137234},
}