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@ARTICLE{Striepens:137252,
      author       = {Striepens, Nadine and Matusch, Andreas and Kendrick, Keith
                      M and Mihov, Yoan and Elmenhorst, David and Becker, Benjamin
                      and Lang, Markus and Coenen, Heinz H and Maier, Wolfgang and
                      Hurlemann, René and Bauer, Andreas},
      title        = {{O}xytocin enhances attractiveness of unfamiliar female
                      faces independent of the dopamine reward system.},
      journal      = {Psychoneuroendocrinology},
      volume       = {39},
      issn         = {0306-4530},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03574},
      pages        = {74-87},
      year         = {2014},
      abstract     = {Evidence from animal studies suggests that the social
                      attraction and bonding effects of the neuropeptide oxytocin
                      (OXT) are mediated by its modulation of dopamine (DA)
                      release in brain reward centers, but this has not yet been
                      demonstrated in humans. DA release can be measured by
                      positron emission tomography (PET) using the radioligand
                      [11C]raclopride. Its binding to DA D2 receptors (D2R) is
                      sensitive and reciprocally related to endogenous DA,
                      especially in the striatum. In a randomized double-blind
                      placebo-controlled within-subjects trial on 18 adult male
                      volunteers we combined [11C]raclopride PET and a facial
                      attractiveness rating task to establish whether intranasal
                      OXT (24 IU) increased both the perceived attractiveness of
                      unfamiliar female faces and striatal DA release compared
                      with placebo administration. While our behavioral data
                      confirmed that subjects rated unfamiliar female faces as
                      more attractive following OXT treatment, and this correlated
                      with an increased perfusion rate in the striatum, there was
                      no evidence for altered [11C]raclopride binding in the
                      striatum or pallidum. Instead under OXT we rather observed
                      an increased [11C]raclopride binding and reduced perfusion
                      rate in subregions of the right dorsomedial prefrontal gyrus
                      and superior parietal gyrus. The absence of OXT effects on
                      dopamine release and D2 receptors in brain reward centers,
                      despite increased striatal activity, implies that the
                      peptide may facilitate perceived attraction via
                      non-dopaminergic actions.},
      keywords     = {Adult / Corpus Striatum: diagnostic imaging / Corpus
                      Striatum: drug effects / Corpus Striatum: metabolism /
                      Dopamine: metabolism / Double-Blind Method / Face / Female /
                      Humans / Male / Oxytocin: pharmacology / Raclopride:
                      pharmacology / Radionuclide Imaging / Raclopride (NLM
                      Chemicals) / Oxytocin (NLM Chemicals) / Dopamine (NLM
                      Chemicals)},
      cin          = {U Clinical Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)7000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24275006},
      doi          = {10.1016/j.psyneuen.2013.09.026},
      url          = {https://pub.dzne.de/record/137252},
}