%0 Journal Article
%A Tzikas, Stergios
%A Schlak, Dennis
%A Sopova, Kateryna
%A Gatsiou, Aikaterini
%A Stakos, Dimitrios
%A Stamatelopoulos, Kimon
%A Stellos, Konstantinos
%A Laske, Christoph
%T Increased myeloperoxidase plasma levels in patients with Alzheimer's disease.
%J Journal of Alzheimer's disease
%V 39
%N 3
%@ 1875-8908
%C Amsterdam
%I IOS Press
%M DZNE-2020-03585
%P 557-564
%D 2014
%X Increasing evidence supports the role of cardiovascular risk factors in the development of Alzheimer’s disease (AD).Objective:In the present pilot study, we investigated plasma concentrations of myeloperoxidase (MPO) and its possible association with plasma amyloid-β (Aβ)1-42/1-40 ratio in AD patients and elderly healthy controls.Methods:The study sample included 28 AD patients and 27 elderly individuals with a normal cognitive status as a control group. The Mini-Mental Status Examination was used to determine the global cognition. MPO, Aβ1-40, and Aβ1-42 plasma concentrations were measured by enzyme linked immunoabsorbent assays.Results:AD patients showed significantly higher plasma concentrations of MPO in comparison to healthy elderly controls (AD versus healthy elderly controls (mean ± SD): 132.8 ± 114.8 ng/mL versus 55.0 ± 42.6 ng/mL; p = 0.002). MPO plasma concentrations showed a significant positive correlation in the whole sample with the presence of AD (ρ = 0.428, p < 0.001) and its stage (ρ = 0.331; p = 0.013) as well as with plasma concentrations of Aβ1-42 (ρ = 0.406; p = 0.004) and Aβ1-42/1-40 ratio (ρ = 0.354; p = 0.013). In a binary logistic regression model, plasma MPO concentrations were independently associated with the presence of AD (p = 0.014).Conclusion:AD patients showed significantly increased plasma levels of MPO, which could be an important molecular link between atherosclerosis and AD. Further studies should evaluate whether MPO may also be a useful biomarker and potential new treatment target in AD.
%K Aged
%K Aged, 80 and over
%K Alzheimer Disease: blood
%K Amyloid beta-Peptides: blood
%K Female
%K Humans
%K Immunoenzyme Techniques
%K Logistic Models
%K Male
%K Mental Status Schedule
%K Neuropsychological Tests
%K Peptide Fragments: blood
%K Peroxidase: blood
%K ROC Curve
%K Amyloid beta-Peptides (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-40) (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K Peroxidase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24217274
%R 10.3233/JAD-131469
%U https://pub.dzne.de/record/137263