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@ARTICLE{Tzikas:137263,
      author       = {Tzikas, Stergios and Schlak, Dennis and Sopova, Kateryna
                      and Gatsiou, Aikaterini and Stakos, Dimitrios and
                      Stamatelopoulos, Kimon and Stellos, Konstantinos and Laske,
                      Christoph},
      title        = {{I}ncreased myeloperoxidase plasma levels in patients with
                      {A}lzheimer's disease.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {39},
      number       = {3},
      issn         = {1875-8908},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2020-03585},
      pages        = {557-564},
      year         = {2014},
      abstract     = {Increasing evidence supports the role of cardiovascular
                      risk factors in the development of Alzheimer’s disease
                      (AD).Objective:In the present pilot study, we investigated
                      plasma concentrations of myeloperoxidase (MPO) and its
                      possible association with plasma amyloid-β (Aβ)1-42/1-40
                      ratio in AD patients and elderly healthy
                      controls.Methods:The study sample included 28 AD patients
                      and 27 elderly individuals with a normal cognitive status as
                      a control group. The Mini-Mental Status Examination was used
                      to determine the global cognition. MPO, Aβ1-40, and Aβ1-42
                      plasma concentrations were measured by enzyme linked
                      immunoabsorbent assays.Results:AD patients showed
                      significantly higher plasma concentrations of MPO in
                      comparison to healthy elderly controls (AD versus healthy
                      elderly controls (mean ± SD): 132.8 ± 114.8 ng/mL versus
                      55.0 ± 42.6 ng/mL; p = 0.002). MPO plasma concentrations
                      showed a significant positive correlation in the whole
                      sample with the presence of AD (ρ = 0.428, p < 0.001) and
                      its stage (ρ = 0.331; p = 0.013) as well as with plasma
                      concentrations of Aβ1-42 (ρ = 0.406; p = 0.004) and
                      Aβ1-42/1-40 ratio (ρ = 0.354; p = 0.013). In a binary
                      logistic regression model, plasma MPO concentrations were
                      independently associated with the presence of AD (p =
                      0.014).Conclusion:AD patients showed significantly increased
                      plasma levels of MPO, which could be an important molecular
                      link between atherosclerosis and AD. Further studies should
                      evaluate whether MPO may also be a useful biomarker and
                      potential new treatment target in AD.},
      keywords     = {Aged / Aged, 80 and over / Alzheimer Disease: blood /
                      Amyloid beta-Peptides: blood / Female / Humans /
                      Immunoenzyme Techniques / Logistic Models / Male / Mental
                      Status Schedule / Neuropsychological Tests / Peptide
                      Fragments: blood / Peroxidase: blood / ROC Curve / Amyloid
                      beta-Peptides (NLM Chemicals) / Peptide Fragments (NLM
                      Chemicals) / amyloid beta-protein (1-40) (NLM Chemicals) /
                      amyloid beta-protein (1-42) (NLM Chemicals) / Peroxidase
                      (NLM Chemicals)},
      cin          = {AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1210001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24217274},
      doi          = {10.3233/JAD-131469},
      url          = {https://pub.dzne.de/record/137263},
}