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000137269 041__ $$aEnglish
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000137269 1001_ $$aNeuner, Johanna$$b0
000137269 245__ $$aA30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.
000137269 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2014
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000137269 520__ $$aImpaired olfaction is an early symptom in Parkinson disease (PD), although the exact cause is as yet unknown. Here, we investigated the link between PD-related mutant α-Synuclein (α-SYN) pathology and olfactory deficit, by examining the integration of adult-born neurons in the olfactory bulb (OB) of A30P α-SYN overexpressing mice. To this end, we chose to label one well-known vulnerable subpopulation of adult-born cells, the dopaminergic neurons. Using in vivo two-photon imaging, we followed the dynamic process of neuronal turnover in transgenic A30P α-SYN and wild-type mice over a period of 2.5 months. Our results reveal no difference in the number of cells that reach, and possibly integrate into, the glomerular layer in the OB. However, in mutant transgenic mice these new neurons have a significantly shortened survival, resulting in an overall reduction in the addition of neurons to the glomerular layer over time. We therefore propose unstable integration and impaired homeostasis of functional new neurons as a likely contributor to odour discrimination deficits in mutant α-SYN mice.
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000137269 650_7 $$2NLM Chemicals$$aSNCA protein, human
000137269 650_7 $$2NLM Chemicals$$aalpha-Synuclein
000137269 650_7 $$0VTD58H1Z2X$$2NLM Chemicals$$aDopamine
000137269 650_2 $$2MeSH$$aAnimals
000137269 650_2 $$2MeSH$$aDopamine: biosynthesis
000137269 650_2 $$2MeSH$$aDopaminergic Neurons: diagnostic imaging
000137269 650_2 $$2MeSH$$aLentivirus: genetics
000137269 650_2 $$2MeSH$$aMice
000137269 650_2 $$2MeSH$$aMice, Inbred C57BL
000137269 650_2 $$2MeSH$$aMice, Transgenic
000137269 650_2 $$2MeSH$$aOlfaction Disorders: genetics
000137269 650_2 $$2MeSH$$aOlfactory Bulb: physiopathology
000137269 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000137269 650_2 $$2MeSH$$aParkinson Disease: genetics
000137269 650_2 $$2MeSH$$aProtein Aggregation, Pathological: metabolism
000137269 650_2 $$2MeSH$$aRadiography
000137269 650_2 $$2MeSH$$aSmell: genetics
000137269 650_2 $$2MeSH$$aSmell: physiology
000137269 650_2 $$2MeSH$$aalpha-Synuclein: genetics
000137269 7001_ $$0P:(DE-2719)2810523$$aFilser, Severin$$b1
000137269 7001_ $$aMichalakis, Stylianos$$b2
000137269 7001_ $$aBiel, Martin$$b3
000137269 7001_ $$0P:(DE-2719)2810441$$aHerms, Jochen$$b4$$eLast author
000137269 77318 $$2Crossref$$3journal-article$$a10.1038/srep03931$$b : Springer Science and Business Media LLC, 2014-02-03$$n1$$p3931$$tScientific Reports$$v4$$x2045-2322$$y2014
000137269 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/srep03931$$gVol. 4, no. 1, p. 3931$$n1$$p3931$$q4:1<3931$$tScientific reports$$v4$$x2045-2322$$y2014
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000137269 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909899
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