Home > Publications Database > A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. > print

001     137269
005     20240605120458.0
024 7 _ |a 10.1038/srep03931
|2 doi
024 7 _ |a pmid:24488133
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024 7 _ |a pmc:PMC3909899
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037 _ _ |a DZNE-2020-03591
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Neuner, Johanna
|b 0
245 _ _ |a A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.
260 _ _ |a [London]
|c 2014
|b Macmillan Publishers Limited, part of Springer Nature
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2014-02-03
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2015-05-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Impaired olfaction is an early symptom in Parkinson disease (PD), although the exact cause is as yet unknown. Here, we investigated the link between PD-related mutant α-Synuclein (α-SYN) pathology and olfactory deficit, by examining the integration of adult-born neurons in the olfactory bulb (OB) of A30P α-SYN overexpressing mice. To this end, we chose to label one well-known vulnerable subpopulation of adult-born cells, the dopaminergic neurons. Using in vivo two-photon imaging, we followed the dynamic process of neuronal turnover in transgenic A30P α-SYN and wild-type mice over a period of 2.5 months. Our results reveal no difference in the number of cells that reach, and possibly integrate into, the glomerular layer in the OB. However, in mutant transgenic mice these new neurons have a significantly shortened survival, resulting in an overall reduction in the addition of neurons to the glomerular layer over time. We therefore propose unstable integration and impaired homeostasis of functional new neurons as a likely contributor to odour discrimination deficits in mutant α-SYN mice.
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542 _ _ |i 2014-02-03
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|u https://creativecommons.org/licenses/by-nc-nd/3.0/
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650 _ 7 |a SNCA protein, human
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650 _ 7 |a alpha-Synuclein
|2 NLM Chemicals
650 _ 7 |a Dopamine
|0 VTD58H1Z2X
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Dopamine: biosynthesis
|2 MeSH
650 _ 2 |a Dopaminergic Neurons: diagnostic imaging
|2 MeSH
650 _ 2 |a Lentivirus: genetics
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Olfaction Disorders: genetics
|2 MeSH
650 _ 2 |a Olfactory Bulb: physiopathology
|2 MeSH
650 _ 2 |a Parkinson Disease: diagnosis
|2 MeSH
650 _ 2 |a Parkinson Disease: genetics
|2 MeSH
650 _ 2 |a Protein Aggregation, Pathological: metabolism
|2 MeSH
650 _ 2 |a Radiography
|2 MeSH
650 _ 2 |a Smell: genetics
|2 MeSH
650 _ 2 |a Smell: physiology
|2 MeSH
650 _ 2 |a alpha-Synuclein: genetics
|2 MeSH
700 1 _ |a Filser, Severin
|0 P:(DE-2719)2810523
|b 1
700 1 _ |a Michalakis, Stylianos
|b 2
700 1 _ |a Biel, Martin
|b 3
700 1 _ |a Herms, Jochen
|0 P:(DE-2719)2810441
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|e Last author
773 1 8 |a 10.1038/srep03931
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|t Scientific Reports
|v 4
|y 2014
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773 _ _ |a 10.1038/srep03931
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856 4 _ |y OpenAccess
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