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@ARTICLE{Wurst:137288,
      author       = {Wurst, Wolfgang and Prakash, Nilima},
      title        = {{W}nt1-regulated genetic networks in midbrain dopaminergic
                      neuron development.},
      journal      = {Journal of molecular cell biology},
      volume       = {6},
      number       = {1},
      issn         = {1674-2788},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-03610},
      pages        = {34-41},
      year         = {2014},
      abstract     = {Neurons synthesizing the neurotransmitter dopamine exert
                      crucial functions in the mammalian brain. The biggest and
                      most important population of dopamine-synthesizing neurons
                      is located in the mammalian ventral midbrain (VM), and
                      controls and modulates the execution of motor, cognitive,
                      affective, motivational, and rewarding behaviours.
                      Degeneration of these neurons leads to motor deficits that
                      are characteristic of Parkinson's disease, while their
                      dysfunction is involved in the pathogenesis of psychiatric
                      disorders including schizophrenia and addiction. Because the
                      aetiology and therapeutic prospects for these diseases
                      include neurodevelopmental aspects, substantial scientific
                      interest has been focused on deciphering the mechanistic
                      pathways that control the generation and survival of these
                      neurons during embryonic development. Researches during the
                      last decade revealed the pivotal role of the secreted Wnt1
                      ligand and its signalling cascade in the generation of the
                      dopamine-synthesizing neurons in the mammalian VM. Here, we
                      summarize the initial and more recent findings that have
                      unravelled several Wnt1-controlled genetic networks required
                      for the proliferation and commitment of VM progenitors to
                      the dopaminergic cell fate during midgestational embryonic
                      stages, and for the correct differentiation of these
                      progenitors into postmitotic dopamine-synthesizing neurons
                      at late midgestational embryonic and foetal stages.},
      subtyp        = {Review Article},
      keywords     = {Animals / Dopaminergic Neurons: cytology / Dopaminergic
                      Neurons: metabolism / Dopaminergic Neurons: physiology /
                      Gene Regulatory Networks / Mesencephalon: cytology / Mice /
                      Models, Biological / Wnt Signaling Pathway: physiology /
                      Wnt1 Protein: genetics / Wnt1 Protein: metabolism / Wnt1
                      Protein: physiology / Wnt1 Protein (NLM Chemicals)},
      cin          = {AG Wurst / Ext HZM},
      ddc          = {570},
      cid          = {I:(DE-2719)1140001 / I:(DE-2719)5000050},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24326514},
      doi          = {10.1093/jmcb/mjt046},
      url          = {https://pub.dzne.de/record/137288},
}