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000137295 0247_ $$2doi$$a10.1016/j.neurobiolaging.2013.10.086
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000137295 037__ $$aDZNE-2020-03617
000137295 041__ $$aEnglish
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000137295 1001_ $$0P:(DE-2719)2813257$$aHarris, Mathew A$$b0$$eFirst author
000137295 245__ $$aHow age-related strategy switching deficits affect wayfinding in complex environments.
000137295 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2014
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000137295 520__ $$aAlthough most research on navigation in aging focuses on allocentric processing deficits, impaired strategy switching may also contribute to navigational decline. Using a specifically designed task involving navigating a town-like virtual environment, we assessed the ability of young and old participants to switch from following learned routes to finding novel shortcuts. We found large age differences in the length of routes taken during testing and in use of shortcuts, as, while nearly all young participants switched from the egocentric route-following strategy to the allocentric wayfinding strategy, none of the older participants stably switched. Although secondary tasks confirmed that older participants were impaired both at strategy switching and allocentric processing, the difficulty in using shortcuts was selectively related to impaired strategy switching. This may in turn relate to dysfunction of the prefrontal-noradrenergic network responsible for coordinating switching behavior. We conclude that the large age difference in performance at the shortcutting task demonstrates for the first time, how strategy switching deficits can have a severe impact on navigation in aging.
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000137295 650_7 $$0X4W3ENH1CV$$2NLM Chemicals$$aNorepinephrine
000137295 650_2 $$2MeSH$$aAdolescent
000137295 650_2 $$2MeSH$$aAdult
000137295 650_2 $$2MeSH$$aAged
000137295 650_2 $$2MeSH$$aAging: physiology
000137295 650_2 $$2MeSH$$aAging: psychology
000137295 650_2 $$2MeSH$$aFemale
000137295 650_2 $$2MeSH$$aHumans
000137295 650_2 $$2MeSH$$aMale
000137295 650_2 $$2MeSH$$aMaze Learning: physiology
000137295 650_2 $$2MeSH$$aMiddle Aged
000137295 650_2 $$2MeSH$$aNerve Net: physiopathology
000137295 650_2 $$2MeSH$$aNorepinephrine: physiology
000137295 650_2 $$2MeSH$$aPrefrontal Cortex: physiopathology
000137295 650_2 $$2MeSH$$aSpace Perception: physiology
000137295 650_2 $$2MeSH$$aSpatial Behavior: physiology
000137295 650_2 $$2MeSH$$aYoung Adult
000137295 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b1$$eLast author
000137295 77318 $$2Crossref$$3journal-article$$a10.1016/j.neurobiolaging.2013.10.086$$b : Elsevier BV, 2014-05-01$$n5$$p1095-1102$$tNeurobiology of Aging$$v35$$x0197-4580$$y2014
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