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@ARTICLE{Harris:137295,
      author       = {Harris, Mathew A and Wolbers, Thomas},
      title        = {{H}ow age-related strategy switching deficits affect
                      wayfinding in complex environments.},
      journal      = {Neurobiology of aging},
      volume       = {35},
      number       = {5},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03617},
      pages        = {1095-1102},
      year         = {2014},
      abstract     = {Although most research on navigation in aging focuses on
                      allocentric processing deficits, impaired strategy switching
                      may also contribute to navigational decline. Using a
                      specifically designed task involving navigating a town-like
                      virtual environment, we assessed the ability of young and
                      old participants to switch from following learned routes to
                      finding novel shortcuts. We found large age differences in
                      the length of routes taken during testing and in use of
                      shortcuts, as, while nearly all young participants switched
                      from the egocentric route-following strategy to the
                      allocentric wayfinding strategy, none of the older
                      participants stably switched. Although secondary tasks
                      confirmed that older participants were impaired both at
                      strategy switching and allocentric processing, the
                      difficulty in using shortcuts was selectively related to
                      impaired strategy switching. This may in turn relate to
                      dysfunction of the prefrontal-noradrenergic network
                      responsible for coordinating switching behavior. We conclude
                      that the large age difference in performance at the
                      shortcutting task demonstrates for the first time, how
                      strategy switching deficits can have a severe impact on
                      navigation in aging.},
      keywords     = {Adolescent / Adult / Aged / Aging: physiology / Aging:
                      psychology / Female / Humans / Male / Maze Learning:
                      physiology / Middle Aged / Nerve Net: physiopathology /
                      Norepinephrine: physiology / Prefrontal Cortex:
                      physiopathology / Space Perception: physiology / Spatial
                      Behavior: physiology / Young Adult / Norepinephrine (NLM
                      Chemicals)},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24239438},
      doi          = {10.1016/j.neurobiolaging.2013.10.086},
      url          = {https://pub.dzne.de/record/137295},
}