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@ARTICLE{Ritter:137332,
      author       = {Ritter, Christoph and Hebart, Martin N and Wolbers, Thomas
                      and Bingel, Ulrike},
      title        = {{R}epresentation of spatial information in key areas of the
                      descending pain modulatory system.},
      journal      = {The journal of neuroscience},
      volume       = {34},
      number       = {13},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.57413},
      reportid     = {DZNE-2020-03654},
      pages        = {4634-4639},
      year         = {2014},
      abstract     = {Behavioral studies have demonstrated that descending pain
                      modulation can be spatially specific, as is evident in
                      placebo analgesia, which can be limited to the location at
                      which pain relief is expected. This suggests that
                      higher-order cortical structures of the descending pain
                      modulatory system carry spatial information about the site
                      of stimulation. Here, we used functional magnetic resonance
                      imaging and multivariate pattern analysis in 15 healthy
                      human volunteers to test whether spatial information of
                      painful stimuli is represented in areas of the descending
                      pain modulatory system. We show that the site of nociceptive
                      stimulation (arm or leg) can be successfully decoded from
                      local patterns of brain activity during the anticipation and
                      receipt of painful stimulation in the rostral anterior
                      cingulate cortex, the dorsolateral prefrontal cortices, and
                      the contralateral parietal operculum. These results
                      demonstrate that information regarding the site of
                      nociceptive stimulation is represented in these brain
                      regions. Attempts to predict arm and leg stimulation from
                      the periaqueductal gray, control regions (e.g., white
                      matter) or the control time interval in the intertrial phase
                      did not allow for classifications above chance level. This
                      finding represents an important conceptual advance in the
                      understanding of endogenous pain control mechanisms by
                      bridging the gap between previous behavioral and
                      neuroimaging studies, suggesting a spatial specificity of
                      endogenous pain control.},
      keywords     = {Adult / Arm: innervation / Brain: blood supply / Brain:
                      physiopathology / Brain Mapping / Cues / Female / Functional
                      Laterality / Healthy Volunteers / Humans / Leg: innervation
                      / Male / Neural Pathways: blood supply / Neural Pathways:
                      physiopathology / Nociception: physiology / Pain: pathology
                      / Pain: physiopathology / Pain Measurement / Pain Threshold:
                      physiology / Time Factors / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24672009},
      pmc          = {pmc:PMC6608122},
      doi          = {10.1523/JNEUROSCI.4342-13.2014},
      url          = {https://pub.dzne.de/record/137332},
}