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000137358 0247_ $$2doi$$a10.1002/hbm.22221
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000137358 0247_ $$2ISSN$$a1097-0193
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000137358 041__ $$aEnglish
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000137358 1001_ $$0P:(DE-HGF)0$$aKoppelmans, Vincent$$b0
000137358 245__ $$aGlobal and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy.
000137358 260__ $$aNew York, NY$$bWiley-Liss$$c2014
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000137358 520__ $$aTo date, only four small studies have investigated the effects of adjuvant chemotherapy for breast cancer on the microstructure of cerebral white matter with magnetic resonance imaging (MRI). These studies, which were conducted shortly up to 10 years post-treatment, showed that chemotherapy is associated with focal loss of microstructural white matter integrity. We investigated the long-term effect of chemotherapy on white matter microstructural integrity by comparing the brains of chemotherapy-exposed breast cancer survivors to those of a population-based sample of women without a history of cancer.Diffusion tensor imaging (DTI) MRI (1.5 T) was performed in 187 CMF (cyclophosphamide, methotrexate, and 5-flourouracil) chemotherapy-exposed breast cancer survivors, mean age 64.2 (sd = 6.5) years, who had been diagnosed with cancer on average 21.2 (sd = 4.4) years before, and 374 age-matched cancer-free reference subjects from a population-based cohort study. Outcome measures were whole-brain microstructural integrity as measured by fractional anisotropy and mean/axial/radial diffusivity and focal white matter integrity, which was analyzed with tract-based spatial statistics. All analyses were adjusted for age, cardiovascular risk factors, education, and symptoms of depression.No significant group differences were observed in white matter integrity. However, within the breast cancer survivors, time since treatment was inversely associated with lower global and focal white matter integrity.This cross-sectional study suggests that among chemotherapy-exposed breast cancer survivors white matter microstructural integrity deteriorates with accumulating time since treatment. This warrants further investigation.
000137358 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
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000137358 650_7 $$2NLM Chemicals$$aAntineoplastic Agents
000137358 650_7 $$08N3DW7272P$$2NLM Chemicals$$aCyclophosphamide
000137358 650_7 $$0U3P01618RT$$2NLM Chemicals$$aFluorouracil
000137358 650_7 $$0YL5FZ2Y5U1$$2NLM Chemicals$$aMethotrexate
000137358 650_2 $$2MeSH$$aAged
000137358 650_2 $$2MeSH$$aAntineoplastic Agents: adverse effects
000137358 650_2 $$2MeSH$$aAntineoplastic Combined Chemotherapy Protocols: adverse effects
000137358 650_2 $$2MeSH$$aBrain: drug effects
000137358 650_2 $$2MeSH$$aBrain: pathology
000137358 650_2 $$2MeSH$$aBreast Neoplasms: drug therapy
000137358 650_2 $$2MeSH$$aChemotherapy, Adjuvant: adverse effects
000137358 650_2 $$2MeSH$$aCross-Sectional Studies
000137358 650_2 $$2MeSH$$aCyclophosphamide: administration & dosage
000137358 650_2 $$2MeSH$$aCyclophosphamide: adverse effects
000137358 650_2 $$2MeSH$$aDiffusion Tensor Imaging: instrumentation
000137358 650_2 $$2MeSH$$aDiffusion Tensor Imaging: methods
000137358 650_2 $$2MeSH$$aFemale
000137358 650_2 $$2MeSH$$aFluorouracil: administration & dosage
000137358 650_2 $$2MeSH$$aFluorouracil: adverse effects
000137358 650_2 $$2MeSH$$aHumans
000137358 650_2 $$2MeSH$$aLeukoencephalopathies: chemically induced
000137358 650_2 $$2MeSH$$aLeukoencephalopathies: pathology
000137358 650_2 $$2MeSH$$aMethotrexate: administration & dosage
000137358 650_2 $$2MeSH$$aMethotrexate: adverse effects
000137358 650_2 $$2MeSH$$aMiddle Aged
000137358 650_2 $$2MeSH$$aSurvivors
000137358 650_2 $$2MeSH$$aTime Factors
000137358 7001_ $$0P:(DE-HGF)0$$ade Groot, Marius$$b1
000137358 7001_ $$0P:(DE-HGF)0$$ade Ruiter, Michiel B$$b2
000137358 7001_ $$0P:(DE-HGF)0$$aBoogerd, Willem$$b3
000137358 7001_ $$0P:(DE-HGF)0$$aSeynaeve, Caroline$$b4
000137358 7001_ $$0P:(DE-HGF)0$$aVernooij, Meike W$$b5
000137358 7001_ $$0P:(DE-HGF)0$$aNiessen, Wiro J$$b6
000137358 7001_ $$0P:(DE-HGF)0$$aSchagen, Sanne B$$b7$$eCorresponding author
000137358 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b8$$eLast author
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