TY  - JOUR
AU  - Wurster, Isabel
AU  - Abaza, Annegret
AU  - Brockmann, Kathrin
AU  - Liepelt-Scarfone, Inga
AU  - Berg, Daniela
TI  - Parkinson's disease with and without preceding essential tremor-similar phenotypes: a pilot study.
JO  - Journal of neurology
VL  - 261
IS  - 5
SN  - 0340-5354
CY  - Berlin
PB  - Springer73057
M1  - DZNE-2020-03712
SP  - 884-888
PY  - 2014
AB  - The aim of this pilot study was to compare clinical aspects of tremor-dominant Parkinson’s disease (PD) patients with and without preceding essential tremor to identify characteristics of these two subgroups. Nineteen patients with diagnoses of both essential tremor (ET) and Parkinson’s disease in comparison to 18 patients with tremor-dominant Parkinson’s disease without preceding tremor were investigated. The profile of several motor and non-motor symptoms, including cognitive dysfunction, depression, sleep alterations, olfaction changes and some autonomic symptoms, as well as imaging aspects obtained by transcranial sonography were compared between groups. Parkinson’s patients with essential tremor scored higher in kinetic and postural tremor items (p < 0.05) and displayed an enlarged third ventricle on transcranial sonography (p = 0.010), which was not found in tremor-dominant Parkinson’s disease patients. All other motor and non-motor symptoms could not distinguish between either study group. Neither group showed a distinct clinical profile related to non-motor symptoms or symptoms other than tremor-specific motor aspects. The fact that non-motor symptoms were similar in ET-PD gives rise to the hypothesis that also the prodromal phase of PD is similar in ET patients later developing classical PD compared to individuals developing PD without preceding ET. This hypothesis needs to be followed in prospective studies to verify whether the establishment of an ET subgroup with prodromal markers for PD is feasible.
KW  - Aged
KW  - Essential Tremor: diagnosis
KW  - Essential Tremor: physiopathology
KW  - Essential Tremor: psychology
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Parkinson Disease: diagnosis
KW  - Parkinson Disease: physiopathology
KW  - Parkinson Disease: psychology
KW  - Phenotype
KW  - Pilot Projects
LB  - PUB:(DE-HGF)16
C6  - pmid:24590404
DO  - DOI:10.1007/s00415-014-7285-z
UR  - https://pub.dzne.de/record/137390
ER  -