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@ARTICLE{Wurster:137390,
      author       = {Wurster, Isabel and Abaza, Annegret and Brockmann, Kathrin
                      and Liepelt-Scarfone, Inga and Berg, Daniela},
      title        = {{P}arkinson's disease with and without preceding essential
                      tremor-similar phenotypes: a pilot study.},
      journal      = {Journal of neurology},
      volume       = {261},
      number       = {5},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer73057},
      reportid     = {DZNE-2020-03712},
      pages        = {884-888},
      year         = {2014},
      abstract     = {The aim of this pilot study was to compare clinical aspects
                      of tremor-dominant Parkinson’s disease (PD) patients with
                      and without preceding essential tremor to identify
                      characteristics of these two subgroups. Nineteen patients
                      with diagnoses of both essential tremor (ET) and
                      Parkinson’s disease in comparison to 18 patients with
                      tremor-dominant Parkinson’s disease without preceding
                      tremor were investigated. The profile of several motor and
                      non-motor symptoms, including cognitive dysfunction,
                      depression, sleep alterations, olfaction changes and some
                      autonomic symptoms, as well as imaging aspects obtained by
                      transcranial sonography were compared between groups.
                      Parkinson’s patients with essential tremor scored higher
                      in kinetic and postural tremor items (p < 0.05) and
                      displayed an enlarged third ventricle on transcranial
                      sonography (p = 0.010), which was not found in
                      tremor-dominant Parkinson’s disease patients. All other
                      motor and non-motor symptoms could not distinguish between
                      either study group. Neither group showed a distinct clinical
                      profile related to non-motor symptoms or symptoms other than
                      tremor-specific motor aspects. The fact that non-motor
                      symptoms were similar in ET-PD gives rise to the hypothesis
                      that also the prodromal phase of PD is similar in ET
                      patients later developing classical PD compared to
                      individuals developing PD without preceding ET. This
                      hypothesis needs to be followed in prospective studies to
                      verify whether the establishment of an ET subgroup with
                      prodromal markers for PD is feasible.},
      keywords     = {Aged / Essential Tremor: diagnosis / Essential Tremor:
                      physiopathology / Essential Tremor: psychology / Female /
                      Humans / Male / Middle Aged / Parkinson Disease: diagnosis /
                      Parkinson Disease: physiopathology / Parkinson Disease:
                      psychology / Phenotype / Pilot Projects},
      cin          = {Biobanking Facility Tübingen / AG Gasser / AG Berg},
      ddc          = {610},
      cid          = {I:(DE-2719)1240004 / I:(DE-2719)1210000 /
                      I:(DE-2719)5000055},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24590404},
      doi          = {10.1007/s00415-014-7285-z},
      url          = {https://pub.dzne.de/record/137390},
}