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000137404 0247_ $$2doi$$a10.1002/embj.201387637
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000137404 0247_ $$2ISSN$$a1460-2075
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000137404 037__ $$aDZNE-2020-03726
000137404 041__ $$aEnglish
000137404 082__ $$a570
000137404 1001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b0$$eFirst author$$udzne
000137404 245__ $$aEpigenetic memory: the Lamarckian brain.
000137404 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2014
000137404 264_1 $$2Crossref$$3online$$bWiley$$c2014-04-09
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000137404 520__ $$aRecent data support the view that epigenetic processes play a role in memory consolidation and help to transmit acquired memories even across generations in a Lamarckian manner. Drugs that target the epigenetic machinery were found to enhance memory function in rodents and ameliorate disease phenotypes in models for brain diseases such as Alzheimer's disease, Chorea Huntington, Depression or Schizophrenia. In this review, I will give an overview on the current knowledge of epigenetic processes in memory function and brain disease with a focus on Morbus Alzheimer as the most common neurodegenerative disease. I will address the question whether an epigenetic therapy could indeed be a suitable therapeutic avenue to treat brain diseases and discuss the necessary steps that should help to take neuroepigenetic research to the next level.
000137404 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000137404 650_7 $$2NLM Chemicals$$aHistones
000137404 650_7 $$2NLM Chemicals$$aRNA, Untranslated
000137404 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000137404 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000137404 650_2 $$2MeSH$$aAnimals
000137404 650_2 $$2MeSH$$aBrain: physiopathology
000137404 650_2 $$2MeSH$$aEpigenesis, Genetic
000137404 650_2 $$2MeSH$$aGene Expression Regulation
000137404 650_2 $$2MeSH$$aHistones: metabolism
000137404 650_2 $$2MeSH$$aHumans
000137404 650_2 $$2MeSH$$aMemory
000137404 650_2 $$2MeSH$$aRNA, Untranslated: physiology
000137404 77318 $$2Crossref$$3journal-article$$a10.1002/embj.201387637$$b : Wiley, 2014-04-09$$n9$$p945-967$$tThe EMBO Journal$$v33$$x0261-4189$$y2014
000137404 773__ $$0PERI:(DE-600)1467419-1$$a10.1002/embj.201387637$$gVol. 33, no. 9, p. 945 - 967$$n9$$p945-967$$q33:9<945 - 967$$tThe EMBO journal$$v33$$x0261-4189$$y2014
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