TY  - JOUR
AU  - Fischer, Andre
TI  - Epigenetic memory: the Lamarckian brain.
JO  - The EMBO journal
VL  - 33
IS  - 9
SN  - 0261-4189
CY  - Hoboken, NJ [u.a.]
PB  - Wiley
M1  - DZNE-2020-03726
SP  - 945-967
PY  - 2014
AB  - Recent data support the view that epigenetic processes play a role in memory consolidation and help to transmit acquired memories even across generations in a Lamarckian manner. Drugs that target the epigenetic machinery were found to enhance memory function in rodents and ameliorate disease phenotypes in models for brain diseases such as Alzheimer's disease, Chorea Huntington, Depression or Schizophrenia. In this review, I will give an overview on the current knowledge of epigenetic processes in memory function and brain disease with a focus on Morbus Alzheimer as the most common neurodegenerative disease. I will address the question whether an epigenetic therapy could indeed be a suitable therapeutic avenue to treat brain diseases and discuss the necessary steps that should help to take neuroepigenetic research to the next level.
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: physiopathology
KW  - Animals
KW  - Brain: physiopathology
KW  - Epigenesis, Genetic
KW  - Gene Expression Regulation
KW  - Histones: metabolism
KW  - Humans
KW  - Memory
KW  - RNA, Untranslated: physiology
KW  - Histones (NLM Chemicals)
KW  - RNA, Untranslated (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24719207
C2  - pmc:PMC4193930
DO  - DOI:10.1002/embj.201387637
UR  - https://pub.dzne.de/record/137404
ER  -