000137449 001__ 137449
000137449 005__ 20240321220242.0
000137449 0247_ $$2doi$$a10.1523/JNEUROSCI.5002-13.2014
000137449 0247_ $$2pmid$$apmid:24948809
000137449 0247_ $$2pmc$$apmc:PMC6608212
000137449 0247_ $$2ISSN$$a0270-6474
000137449 0247_ $$2ISSN$$a1529-2401
000137449 0247_ $$2altmetric$$aaltmetric:2448613
000137449 037__ $$aDZNE-2020-03771
000137449 041__ $$aEnglish
000137449 082__ $$a610
000137449 1001_ $$0P:(DE-HGF)0$$aBodea, Liviu-Gabriel$$b0
000137449 245__ $$aNeurodegeneration by activation of the microglial complement-phagosome pathway.
000137449 260__ $$aWashington, DC$$bSoc.57413$$c2014
000137449 264_1 $$2Crossref$$3online$$bSociety for Neuroscience$$c2014-06-18
000137449 264_1 $$2Crossref$$3print$$bSociety for Neuroscience$$c2014-06-18
000137449 3367_ $$2DRIVER$$aarticle
000137449 3367_ $$2DataCite$$aOutput Types/Journal article
000137449 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1585311018_16440
000137449 3367_ $$2BibTeX$$aARTICLE
000137449 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000137449 3367_ $$00$$2EndNote$$aJournal Article
000137449 520__ $$aSystemic inflammatory reactions have been postulated to exacerbate neurodegenerative diseases via microglial activation. We now demonstrate in vivo that repeated systemic challenge of mice over four consecutive days with bacterial LPS maintained an elevated microglial inflammatory phenotype and induced loss of dopaminergic neurons in the substantia nigra. The same total cumulative LPS dose given within a single application did not induce neurodegeneration. Whole-genome transcriptome analysis of the brain demonstrated that repeated systemic LPS application induced an activation pattern involving the classical complement system and its associated phagosome pathway. Loss of dopaminergic neurons induced by repeated systemic LPS application was rescued in complement C3-deficient mice, confirming the involvement of the complement system in neurodegeneration. Our data demonstrate that a phagosomal inflammatory response of microglia is leading to complement-mediated loss of dopaminergic neurons.
000137449 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000137449 588__ $$aDataset connected to CrossRef, PubMed,
000137449 650_7 $$2NLM Chemicals$$aComplement C3
000137449 650_7 $$09007-36-7$$2NLM Chemicals$$aComplement System Proteins
000137449 650_2 $$2MeSH$$aAnimals
000137449 650_2 $$2MeSH$$aComplement Activation: physiology
000137449 650_2 $$2MeSH$$aComplement C3: metabolism
000137449 650_2 $$2MeSH$$aComplement System Proteins: physiology
000137449 650_2 $$2MeSH$$aDopaminergic Neurons: metabolism
000137449 650_2 $$2MeSH$$aDopaminergic Neurons: pathology
000137449 650_2 $$2MeSH$$aMale
000137449 650_2 $$2MeSH$$aMice
000137449 650_2 $$2MeSH$$aMice, 129 Strain
000137449 650_2 $$2MeSH$$aMice, Inbred C57BL
000137449 650_2 $$2MeSH$$aMice, Knockout
000137449 650_2 $$2MeSH$$aMicroglia: metabolism
000137449 650_2 $$2MeSH$$aMicroglia: pathology
000137449 650_2 $$2MeSH$$aNerve Degeneration: metabolism
000137449 650_2 $$2MeSH$$aNerve Degeneration: pathology
000137449 650_2 $$2MeSH$$aNeural Pathways: physiology
000137449 650_2 $$2MeSH$$aPhagosomes: metabolism
000137449 650_2 $$2MeSH$$aPhagosomes: pathology
000137449 650_2 $$2MeSH$$aPhagosomes: physiology
000137449 7001_ $$0P:(DE-HGF)0$$aWang, Yiner$$b1
000137449 7001_ $$0P:(DE-HGF)0$$aLinnartz-Gerlach, Bettina$$b2
000137449 7001_ $$0P:(DE-HGF)0$$aKopatz, Jens$$b3
000137449 7001_ $$0P:(DE-HGF)0$$aSinkkonen, Lasse$$b4
000137449 7001_ $$0P:(DE-2719)2810507$$aMusgrove, Ruth$$b5$$udzne
000137449 7001_ $$0P:(DE-HGF)0$$aKaoma, Tony$$b6
000137449 7001_ $$0P:(DE-HGF)0$$aMuller, Arnaud$$b7
000137449 7001_ $$0P:(DE-HGF)0$$aVallar, Laurent$$b8
000137449 7001_ $$0P:(DE-2719)2481741$$aDi Monte, Donato A$$b9$$udzne
000137449 7001_ $$0P:(DE-HGF)0$$aBalling, Rudi$$b10
000137449 7001_ $$0P:(DE-HGF)0$$aNeumann, Harald$$b11$$eCorresponding author
000137449 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.5002-13.2014$$bSociety for Neuroscience$$d2014-06-18$$n25$$p8546-8556$$tJournal of Neuroscience$$v34$$x0270-6474$$y2014
000137449 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.5002-13.2014$$gVol. 34, no. 25, p. 8546 - 8556$$n25$$p8546-8556$$q34:25<8546 - 8556$$tThe journal of neuroscience$$v34$$x0270-6474$$y2014
000137449 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608212
000137449 909CO $$ooai:pub.dzne.de:137449$$pVDB
000137449 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810507$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000137449 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2481741$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000137449 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000137449 9141_ $$y2014
000137449 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROSCI : 2017
000137449 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000137449 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000137449 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000137449 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000137449 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000137449 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000137449 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000137449 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000137449 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000137449 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000137449 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000137449 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000137449 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ NEUROSCI : 2017
000137449 9201_ $$0I:(DE-2719)1013008$$kAG Di Monte$$lNeurodegeneration and Neuroprotection in Parkinson´s Disease$$x0
000137449 980__ $$ajournal
000137449 980__ $$aVDB
000137449 980__ $$aI:(DE-2719)1013008
000137449 980__ $$aUNRESTRICTED