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000137478 0247_ $$2doi$$a10.1371/journal.pone.0101124
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000137478 041__ $$aEnglish
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000137478 1001_ $$aMeier, Florian$$b0
000137478 245__ $$aFGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.
000137478 260__ $$aSan Francisco, California, US$$bPLOS$$c2014
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000137478 520__ $$aThe normal cellular organization and layering of the vertebrate cerebellum is established during embryonic and early postnatal development by the interplay of a complex array of genetic and signaling pathways. Disruption of these processes and of the proper layering of the cerebellum usually leads to ataxic behaviors. Here, we analyzed the relative contribution of Fibroblast growth factor receptor 2 (FGFR2)-mediated signaling to cerebellar development in conditional Fgfr2 single mutant mice. We show that during embryonic mouse development, Fgfr2 expression is higher in the anterior cerebellar primordium and excluded from the proliferative ventricular neuroepithelium. Consistent with this finding, conditional Fgfr2 single mutant mice display the most prominent defects in the anterior lobules of the adult cerebellum. In this context, FGFR2-mediated signaling is required for the proper generation of Bergmann glia cells and the correct positioning of these cells within the Purkinje cell layer, and for cell survival in the developing cerebellar primordium. Using cerebellar microexplant cultures treated with an FGFR agonist (FGF9) or antagonist (SU5402), we also show that FGF9/FGFR-mediated signaling inhibits the outward migration of radial glia and Bergmann glia precursors and cells, and might thus act as a positioning cue for these cells. Altogether, our findings reveal the specific functions of the FGFR2-mediated signaling pathway in the generation and positioning of Bergmann glia cells during cerebellar development in the mouse.
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000137478 542__ $$2Crossref$$i2014-07-01$$uhttp://creativecommons.org/licenses/by/4.0/
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000137478 650_7 $$062031-54-3$$2NLM Chemicals$$aFibroblast Growth Factors
000137478 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aFgfr2 protein, mouse
000137478 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aReceptor, Fibroblast Growth Factor, Type 2
000137478 650_2 $$2MeSH$$aAnimals
000137478 650_2 $$2MeSH$$aCell Survival
000137478 650_2 $$2MeSH$$aCerebellum: cytology
000137478 650_2 $$2MeSH$$aCerebellum: embryology
000137478 650_2 $$2MeSH$$aCerebellum: metabolism
000137478 650_2 $$2MeSH$$aFibroblast Growth Factors: metabolism
000137478 650_2 $$2MeSH$$aMice
000137478 650_2 $$2MeSH$$aMice, Inbred C57BL
000137478 650_2 $$2MeSH$$aMice, Knockout
000137478 650_2 $$2MeSH$$aNeuroglia: cytology
000137478 650_2 $$2MeSH$$aNeuroglia: metabolism
000137478 650_2 $$2MeSH$$aReceptor, Fibroblast Growth Factor, Type 2: genetics
000137478 650_2 $$2MeSH$$aReceptor, Fibroblast Growth Factor, Type 2: metabolism
000137478 650_2 $$2MeSH$$aSignal Transduction
000137478 7001_ $$aGiesert, Florian$$b1
000137478 7001_ $$aDelic, Sabit$$b2
000137478 7001_ $$0P:(DE-HGF)0$$aFaus-Kessler, Theresa$$b3
000137478 7001_ $$aMatheus, Friederike$$b4
000137478 7001_ $$aSimeone, Antonio$$b5
000137478 7001_ $$aHölter, Sabine M$$b6
000137478 7001_ $$aKühn, Ralf$$b7
000137478 7001_ $$0P:(DE-2719)9000331$$aVogt-Weisenhorn, Daniela$$b8$$udzne
000137478 7001_ $$0P:(DE-HGF)0$$aWurst, Wolfgang$$b9$$eCorresponding author
000137478 7001_ $$0P:(DE-HGF)0$$aPrakash, Nilima$$b10
000137478 77318 $$2Crossref$$3journal-article$$a10.1371/journal.pone.0101124$$b : Public Library of Science (PLoS), 2014-07-01$$n7$$pe101124$$tPLoS ONE$$v9$$x1932-6203$$y2014
000137478 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0101124$$gVol. 9, no. 7, p. e101124 -$$n7$$pe101124$$q9:7<e101124 -$$tPLOS ONE$$v9$$x1932-6203$$y2014
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000137478 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077754
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