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@ARTICLE{Meier:137478,
      author       = {Meier, Florian and Giesert, Florian and Delic, Sabit and
                      Faus-Kessler, Theresa and Matheus, Friederike and Simeone,
                      Antonio and Hölter, Sabine M and Kühn, Ralf and
                      Vogt-Weisenhorn, Daniela and Wurst, Wolfgang and Prakash,
                      Nilima},
      title        = {{FGF}/{FGFR}2 signaling regulates the generation and
                      correct positioning of {B}ergmann glia cells in the
                      developing mouse cerebellum.},
      journal      = {PLOS ONE},
      volume       = {9},
      number       = {7},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2020-03800},
      pages        = {e101124},
      year         = {2014},
      abstract     = {The normal cellular organization and layering of the
                      vertebrate cerebellum is established during embryonic and
                      early postnatal development by the interplay of a complex
                      array of genetic and signaling pathways. Disruption of these
                      processes and of the proper layering of the cerebellum
                      usually leads to ataxic behaviors. Here, we analyzed the
                      relative contribution of Fibroblast growth factor receptor 2
                      (FGFR2)-mediated signaling to cerebellar development in
                      conditional Fgfr2 single mutant mice. We show that during
                      embryonic mouse development, Fgfr2 expression is higher in
                      the anterior cerebellar primordium and excluded from the
                      proliferative ventricular neuroepithelium. Consistent with
                      this finding, conditional Fgfr2 single mutant mice display
                      the most prominent defects in the anterior lobules of the
                      adult cerebellum. In this context, FGFR2-mediated signaling
                      is required for the proper generation of Bergmann glia cells
                      and the correct positioning of these cells within the
                      Purkinje cell layer, and for cell survival in the developing
                      cerebellar primordium. Using cerebellar microexplant
                      cultures treated with an FGFR agonist (FGF9) or antagonist
                      (SU5402), we also show that FGF9/FGFR-mediated signaling
                      inhibits the outward migration of radial glia and Bergmann
                      glia precursors and cells, and might thus act as a
                      positioning cue for these cells. Altogether, our findings
                      reveal the specific functions of the FGFR2-mediated
                      signaling pathway in the generation and positioning of
                      Bergmann glia cells during cerebellar development in the
                      mouse.},
      keywords     = {Animals / Cell Survival / Cerebellum: cytology /
                      Cerebellum: embryology / Cerebellum: metabolism / Fibroblast
                      Growth Factors: metabolism / Mice / Mice, Inbred C57BL /
                      Mice, Knockout / Neuroglia: cytology / Neuroglia: metabolism
                      / Receptor, Fibroblast Growth Factor, Type 2: genetics /
                      Receptor, Fibroblast Growth Factor, Type 2: metabolism /
                      Signal Transduction / Fibroblast Growth Factors (NLM
                      Chemicals) / Fgfr2 protein, mouse (NLM Chemicals) /
                      Receptor, Fibroblast Growth Factor, Type 2 (NLM Chemicals)},
      cin          = {Ext HZM},
      ddc          = {610},
      cid          = {I:(DE-2719)5000050},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24983448},
      pmc          = {pmc:PMC4077754},
      doi          = {10.1371/journal.pone.0101124},
      url          = {https://pub.dzne.de/record/137478},
}