000137497 001__ 137497
000137497 005__ 20240321220248.0
000137497 0247_ $$2doi$$a10.1016/j.neuron.2014.07.004
000137497 0247_ $$2pmid$$apmid:25066086
000137497 0247_ $$2ISSN$$a0896-6273
000137497 0247_ $$2ISSN$$a1097-4199
000137497 0247_ $$2altmetric$$aaltmetric:2536040
000137497 037__ $$aDZNE-2020-03819
000137497 041__ $$aEnglish
000137497 082__ $$a610
000137497 1001_ $$0P:(DE-HGF)0$$aKhodosevich, Konstantin$$b0
000137497 245__ $$aCoexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function.
000137497 260__ $$aNew York, NY$$bElsevier$$c2014
000137497 264_1 $$2Crossref$$3print$$bElsevier BV$$c2014-08-01
000137497 3367_ $$2DRIVER$$aarticle
000137497 3367_ $$2DataCite$$aOutput Types/Journal article
000137497 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1710768094_18976
000137497 3367_ $$2BibTeX$$aARTICLE
000137497 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000137497 3367_ $$00$$2EndNote$$aJournal Article
000137497 520__ $$aGating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 in dentate gyrus (DG) granule cells, since both subunits are highly expressed in this cell type. TARP γ-8 and CKAMP44 decrease the rate of deactivation but have an opposing influence on receptor desensitization, which accounts for their differential modulation of synaptic short-term plasticity. Furthermore, long-term plasticity (LTP) requires TARP γ-8 but not CKAMP44. The coexpression of both auxiliary subunits is necessary for the efficient targeting of AMPARs to the cell surface of DG granule cells. Finally, electrophysiological and biochemical evidence support the notion that CKAMP44 and TARP γ-8 can be contained in the same AMPAR complex.
000137497 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000137497 542__ $$2Crossref$$i2014-08-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000137497 542__ $$2Crossref$$i2015-08-06$$uhttps://www.elsevier.com/open-access/userlicense/1.0/
000137497 588__ $$aDataset connected to CrossRef, PubMed,
000137497 650_7 $$2NLM Chemicals$$aCKAMP44 protein, mouse
000137497 650_7 $$2NLM Chemicals$$aCalcium Channels
000137497 650_7 $$2NLM Chemicals$$aMembrane Proteins
000137497 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000137497 650_7 $$2NLM Chemicals$$aReceptors, AMPA
000137497 650_7 $$2NLM Chemicals$$aTARP gamma-8 protein, mouse
000137497 650_2 $$2MeSH$$aAnimals
000137497 650_2 $$2MeSH$$aCalcium Channels: metabolism
000137497 650_2 $$2MeSH$$aDentate Gyrus: metabolism
000137497 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: physiology
000137497 650_2 $$2MeSH$$aGene Knockout Techniques
000137497 650_2 $$2MeSH$$aHumans
000137497 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000137497 650_2 $$2MeSH$$aMice
000137497 650_2 $$2MeSH$$aNerve Tissue Proteins: metabolism
000137497 650_2 $$2MeSH$$aNeuronal Plasticity: genetics
000137497 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000137497 650_2 $$2MeSH$$aNeurons: metabolism
000137497 650_2 $$2MeSH$$aNeurons: physiology
000137497 650_2 $$2MeSH$$aPatch-Clamp Techniques: methods
000137497 650_2 $$2MeSH$$aReceptors, AMPA: genetics
000137497 650_2 $$2MeSH$$aReceptors, AMPA: metabolism
000137497 650_2 $$2MeSH$$aSynapses: physiology
000137497 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000137497 7001_ $$0P:(DE-2719)2810598$$aJacobi, Eric$$b1
000137497 7001_ $$0P:(DE-2719)2810462$$aFarrow, Paul$$b2
000137497 7001_ $$0P:(DE-HGF)0$$aSchulmann, Anton$$b3
000137497 7001_ $$0P:(DE-HGF)0$$aRusu, Alexandru$$b4
000137497 7001_ $$0P:(DE-HGF)0$$aZhang, Ling$$b5
000137497 7001_ $$0P:(DE-HGF)0$$aSprengel, Rolf$$b6
000137497 7001_ $$0P:(DE-HGF)0$$aMonyer, Hannah$$b7
000137497 7001_ $$0P:(DE-2719)2810460$$aEngelhardt, Jakob$$b8$$eLast author
000137497 77318 $$2Crossref$$3journal-article$$a10.1016/j.neuron.2014.07.004$$b : Elsevier BV, 2014-08-01$$n3$$p601-615$$tNeuron$$v83$$x0896-6273$$y2014
000137497 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2014.07.004$$gVol. 83, no. 3, p. 601 - 615$$n3$$p601-615$$q83:3<601 - 615$$tNeuron$$v83$$x0896-6273$$y2014
000137497 8564_ $$uhttps://pub.dzne.de/record/137497/files/DZNE-2020-03819_Restricted.pdf
000137497 8564_ $$uhttps://pub.dzne.de/record/137497/files/DZNE-2020-03819_Restricted.pdf?subformat=pdfa$$xpdfa
000137497 909CO $$ooai:pub.dzne.de:137497$$pVDB
000137497 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810598$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000137497 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810462$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000137497 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810460$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000137497 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000137497 9141_ $$y2014
000137497 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000137497 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000137497 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000137497 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEURON : 2017
000137497 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000137497 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000137497 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000137497 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000137497 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000137497 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000137497 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000137497 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000137497 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000137497 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNEURON : 2017
000137497 9201_ $$0I:(DE-2719)1013023$$kAG Engelhardt$$lSynaptic Signalling and Neurodegeneration$$x0
000137497 980__ $$ajournal
000137497 980__ $$aVDB
000137497 980__ $$aI:(DE-2719)1013023
000137497 980__ $$aUNRESTRICTED