TY  - JOUR
AU  - Khodosevich, Konstantin
AU  - Jacobi, Eric
AU  - Farrow, Paul
AU  - Schulmann, Anton
AU  - Rusu, Alexandru
AU  - Zhang, Ling
AU  - Sprengel, Rolf
AU  - Monyer, Hannah
AU  - Engelhardt, Jakob
TI  - Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function.
JO  - Neuron
VL  - 83
IS  - 3
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2020-03819
SP  - 601-615
PY  - 2014
AB  - Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 in dentate gyrus (DG) granule cells, since both subunits are highly expressed in this cell type. TARP γ-8 and CKAMP44 decrease the rate of deactivation but have an opposing influence on receptor desensitization, which accounts for their differential modulation of synaptic short-term plasticity. Furthermore, long-term plasticity (LTP) requires TARP γ-8 but not CKAMP44. The coexpression of both auxiliary subunits is necessary for the efficient targeting of AMPARs to the cell surface of DG granule cells. Finally, electrophysiological and biochemical evidence support the notion that CKAMP44 and TARP γ-8 can be contained in the same AMPAR complex.
KW  - Animals
KW  - Calcium Channels: metabolism
KW  - Dentate Gyrus: metabolism
KW  - Excitatory Postsynaptic Potentials: physiology
KW  - Gene Knockout Techniques
KW  - Humans
KW  - Membrane Proteins: metabolism
KW  - Mice
KW  - Nerve Tissue Proteins: metabolism
KW  - Neuronal Plasticity: genetics
KW  - Neuronal Plasticity: physiology
KW  - Neurons: metabolism
KW  - Neurons: physiology
KW  - Patch-Clamp Techniques: methods
KW  - Receptors, AMPA: genetics
KW  - Receptors, AMPA: metabolism
KW  - Synapses: physiology
KW  - Synaptic Transmission: physiology
KW  - CKAMP44 protein, mouse (NLM Chemicals)
KW  - Calcium Channels (NLM Chemicals)
KW  - Membrane Proteins (NLM Chemicals)
KW  - Nerve Tissue Proteins (NLM Chemicals)
KW  - Receptors, AMPA (NLM Chemicals)
KW  - TARP gamma-8 protein, mouse (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25066086
DO  - DOI:10.1016/j.neuron.2014.07.004
UR  - https://pub.dzne.de/record/137497
ER  -