%0 Journal Article
%A Corradini, Eleonora
%A Vallur, Raghavan
%A Raaijmakers, Linsey M
%A Feil, Susanne
%A Feil, Robert
%A Heck, Albert J R
%A Scholten, Arjen
%T Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
%J Molecular & cellular proteomics
%V 13
%N 8
%@ 1535-9476
%C Bethesda, Md.
%I The American Society for Biochemistry and Molecular Biology
%M DZNE-2020-03824
%P 2004-2016
%D 2014
%X The cyclic nucleotide cyclic guanosine monophosphate (cGMP) plays an important role in learning and memory, but its signaling mechanisms in the mammalian brain are not fully understood. Using mass-spectrometry-based proteomics, we evaluated how the cerebellum adapts its (phospho)proteome in a knockout mouse model of cGMP-dependent protein kinase type I (cGKI). Our data reveal that a small subset of proteins in the cerebellum (∼3
%K Animals
%K Cerebellum: metabolism
%K Cyclic GMP
%K Cyclic GMP-Dependent Protein Kinase Type I: genetics
%K Cyclic GMP-Dependent Protein Kinase Type I: metabolism
%K Mice
%K Mice, Knockout
%K Phosphoproteins: isolation & purification
%K Phosphorylation
%K Proteomics: methods
%K Signal Transduction
%K Synapses: metabolism
%K Phosphoproteins (NLM Chemicals)
%K Cyclic GMP-Dependent Protein Kinase Type I (NLM Chemicals)
%K Prkg1 protein, mouse (NLM Chemicals)
%K Cyclic GMP (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24925903
%2 pmc:PMC4125733
%R 10.1074/mcp.M113.035154
%U https://pub.dzne.de/record/137502