TY  - JOUR
AU  - Corradini, Eleonora
AU  - Vallur, Raghavan
AU  - Raaijmakers, Linsey M
AU  - Feil, Susanne
AU  - Feil, Robert
AU  - Heck, Albert J R
AU  - Scholten, Arjen
TI  - Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
JO  - Molecular & cellular proteomics
VL  - 13
IS  - 8
SN  - 1535-9476
CY  - Bethesda, Md.
PB  - The American Society for Biochemistry and Molecular Biology
M1  - DZNE-2020-03824
SP  - 2004-2016
PY  - 2014
AB  - The cyclic nucleotide cyclic guanosine monophosphate (cGMP) plays an important role in learning and memory, but its signaling mechanisms in the mammalian brain are not fully understood. Using mass-spectrometry-based proteomics, we evaluated how the cerebellum adapts its (phospho)proteome in a knockout mouse model of cGMP-dependent protein kinase type I (cGKI). Our data reveal that a small subset of proteins in the cerebellum (∼3
KW  - Animals
KW  - Cerebellum: metabolism
KW  - Cyclic GMP
KW  - Cyclic GMP-Dependent Protein Kinase Type I: genetics
KW  - Cyclic GMP-Dependent Protein Kinase Type I: metabolism
KW  - Mice
KW  - Mice, Knockout
KW  - Phosphoproteins: isolation & purification
KW  - Phosphorylation
KW  - Proteomics: methods
KW  - Signal Transduction
KW  - Synapses: metabolism
KW  - Phosphoproteins (NLM Chemicals)
KW  - Cyclic GMP-Dependent Protein Kinase Type I (NLM Chemicals)
KW  - Prkg1 protein, mouse (NLM Chemicals)
KW  - Cyclic GMP (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24925903
C2  - pmc:PMC4125733
DO  - DOI:10.1074/mcp.M113.035154
UR  - https://pub.dzne.de/record/137502
ER  -