TY  - JOUR
AU  - Szentkirályi, András
AU  - Völzke, Henry
AU  - Hoffmann, Wolfgang
AU  - Trenkwalder, Claudia
AU  - Berger, Klaus
TI  - Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies.
JO  - Neurology
VL  - 82
IS  - 22
SN  - 0028-3878
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-03897
SP  - 2026-2033
PY  - 2014
AB  - Our aim was to evaluate the association between the cumulative effect of comorbidity and the risk of restless legs syndrome (RLS) in 2 population-based German cohort studies.The Dortmund Health Study (DHS) (n = 1,312; median follow-up time: 2.1 years) and the Study of Health in Pomerania (SHIP) (n = 4,308; median follow-up time: 5.0 years) were used for the analyses. RLS was assessed at baseline and follow-up according to the RLS minimal criteria. A comorbidity index was calculated as a sum of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. The relationship between comorbidity and incident RLS was analyzed with multivariate logistic regression models.An increase in the number of comorbid conditions at baseline predicted prevalent RLS (DHS: trend odds ratio [OR] = 1.24, 95
KW  - Adult
KW  - Aged
KW  - Comorbidity
KW  - Female
KW  - Germany: epidemiology
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Prevalence
KW  - Prospective Studies
KW  - Restless Legs Syndrome: epidemiology
KW  - Risk Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:24808014
DO  - DOI:10.1212/WNL.0000000000000470
UR  - https://pub.dzne.de/record/137575
ER  -