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@ARTICLE{Szentkirlyi:137575,
      author       = {Szentkirályi, András and Völzke, Henry and Hoffmann,
                      Wolfgang and Trenkwalder, Claudia and Berger, Klaus},
      title        = {{M}ultimorbidity and the risk of restless legs syndrome in
                      2 prospective cohort studies.},
      journal      = {Neurology},
      volume       = {82},
      number       = {22},
      issn         = {0028-3878},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DZNE-2020-03897},
      pages        = {2026-2033},
      year         = {2014},
      abstract     = {Our aim was to evaluate the association between the
                      cumulative effect of comorbidity and the risk of restless
                      legs syndrome (RLS) in 2 population-based German cohort
                      studies.The Dortmund Health Study (DHS) (n = 1,312; median
                      follow-up time: 2.1 years) and the Study of Health in
                      Pomerania (SHIP) (n = 4,308; median follow-up time: 5.0
                      years) were used for the analyses. RLS was assessed at
                      baseline and follow-up according to the RLS minimal
                      criteria. A comorbidity index was calculated as a sum of the
                      following conditions: diabetes, hypertension, myocardial
                      infarction, obesity, stroke, cancer, renal disease, anemia,
                      depression, thyroid disease, and migraine. The relationship
                      between comorbidity and incident RLS was analyzed with
                      multivariate logistic regression models.An increase in the
                      number of comorbid conditions at baseline predicted
                      prevalent RLS (DHS: trend odds ratio [OR] = 1.24, $95\%$
                      confidence interval [CI] 0.99-1.56; SHIP: trend OR = 1.34,
                      $95\%$ CI 1.18-1.52) and incident RLS (DHS: trend OR = 1.32,
                      $95\%$ CI 1.04-1.68; SHIP: trend OR = 1.59, $95\%$ CI
                      1.37-1.85) after adjustment for several covariates. The ORs
                      for incident RLS associated with 3 or more comorbid diseases
                      (DHS: OR = 2.51, $95\%$ CI 1.18-5.34; SHIP: OR = 4.30,
                      $95\%$ CI 2.60-7.11) were higher than the ORs for any single
                      disease.Multimorbidity was a strong risk factor for RLS in
                      these 2 population-based cohort studies. The results support
                      the hypothesis that cumulative disease burden is more
                      important than the presence of a specific single disease in
                      the pathophysiology of RLS.},
      keywords     = {Adult / Aged / Comorbidity / Female / Germany: epidemiology
                      / Humans / Male / Middle Aged / Prevalence / Prospective
                      Studies / Restless Legs Syndrome: epidemiology / Risk
                      Factors},
      cin          = {Translational Health Care Research},
      ddc          = {610},
      cid          = {I:(DE-2719)1510600},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24808014},
      doi          = {10.1212/WNL.0000000000000470},
      url          = {https://pub.dzne.de/record/137575},
}